P4553
6-磷酸葡糖酸脱氢酶 来源于酵母
lyophilized powder, ≥3.0 units/mg solid
别名:
6-磷酸- D -葡萄糖酸盐：NADP + 2-氧化还原酶（脱羧酶）, 6-磷酸葡糖酸脱氢酶 来源于酵母
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
≥3.0 units/mg solid
Biological source:
yeast
biological source
yeast
form
lyophilized powder
specific activity
≥3.0 units/mg solid
mol wt
52 kDa
storage temp.
2-8°C
Quality Level
General description
来自酵母的6-磷酸葡萄糖酸脱氢酶包含NADP +结合结构域、α螺旋疏水相互作用结构域和C-末端结构域。它以二聚体的形式存在，C末端区域对于底物的结合和释放至关重要。
Application
来自酵母的6-磷酸葡萄糖酸脱氢酶已被用于确定细胞裂解物中的己糖激酶（HK）和木糖还原酶（XR）活性。
Biochem/physiol Actions
通过测量NAD +或NADP +的减少来确定酶活性。据信高水平的NADPH会抑制该酶，而6-磷酸葡萄糖酸酯则可激活该酶。
Other Notes
在存在NADP+的条件下，在37°C下，每分钟1个单位将1.0μmol的6-磷酸-D葡萄糖酸氧化为D-核糖5-磷酸和CO2。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
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Enhancement of xylose uptake in 2-deoxyglucose tolerant mutant of Saccharomyces cerevisiae
Kahar P, et al.
Journal of Bioscience and Bioengineering, 111(5), 557-563 (2011)
Crystal structure of Saccharomyces cerevisiae 6-phosphogluconate dehydrogenase Gnd1
He W, et al.
BMC Structural Biology, 7(1), 38-38 (2007)
G Martínez-Drets et al.
Journal of bacteriology, 130(3), 1139-1143 (1977-06-01)
6-Phospho-D-gluconate:NAD+ 2-oxidoreductase (decarboxylating) (NAD+-6PGD) was detected in several slow-growing strains of rhizobia, and no activity involving NADP+ was found in the same extracts. By contrast, fast-growing strains of rhizobia had NADP+-6PGD activity; most of them also had NAD+-6PGD activity. NAD+-6PGD
Ai-Hua Jin et al.
BMC structural biology, 7, 28-28 (2007-04-21)
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