一般描述
β-内酰胺酶是29 kDa的单体酶。该产品由阴沟肠杆菌生产，以冻干粉形式提供。它可充当β-内酰胺抗生素的靶蛋白。该酶存在于革兰氏阴性菌中。
应用
β-内酰胺酶可通过打开β-内酰胺环来使β-内酰胺抗生素失活。 β-内酰胺酶可用于研究抗生素耐药性和耐药性抑制。 产品P4524由阴沟肠杆菌生产，以冻干粉形式提供。
β-来自阴沟肠杆菌的内酰胺酶已被用于母婴定量血液培养，以避免任何残留现象。它还被用作胎盘培养用Mueller Hinton（MH）肉汤的成分。
生化/生理作用
β-内酰胺酶被用于通过打开 β-内酰胺环灭活β-内酰胺类抗生素。
单位定义
一个单元将在25°C，ph7.0 时每分钟水解 1.0μmol苄青霉素。此国际单位（以苄青霉素为底物）约等于 600levy 或 75pollock 单位。
外形
含有磷酸钠缓冲盐的冻干粉
分析说明
缩二脲法测定蛋白
抑制剂
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
常规特殊物品
Persistent bacteremia in rabbit fetuses despite maternal antibiotic therapy in a novel intrauterine-infection model
Gras-Le Guen C, et al.
Antimicrobial Agents and Chemotherapy, 47(7), 2125-2130 (2003)
Protein-protein interactions monitored in mammalian cells via complementation of beta-lactamase enzyme fragments
Wehrman T, et al.
Proceedings of the National Academy of Sciences of the USA, 99(6), 3469-3474 (2002)
Past and present perspectives on beta$-lactamases
Bush K
Antimicrobial Agents and Chemotherapy, 62(10) (2018)
Jung-Ho Shin et al.
EMBO reports, 22(2), e51790-e51790 (2021-01-20)
Bactericidal antibiotics are powerful agents due to their ability to convert essential bacterial functions into lethal processes. However, many important bacterial pathogens are remarkably tolerant against bactericidal antibiotics due to inducible damage repair responses. The cell wall damage response two-component
P J Johnsen et al.
Genetics, 181(4), 1521-1533 (2009-02-05)
We present a new hypothesis for the selective pressures responsible for maintaining natural competence and transformation. Our hypothesis is based in part on the observation that in Bacillus subtilis, where transformation is widespread, competence is associated with periods of nongrowth
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