P4405
鬼臼毒素
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关于此项目
经验公式（希尔记法）:
C22H22O8
化学文摘社编号:
分子量:
414.41
UNSPSC Code:
12352200
NACRES:
NA.77
PubChem Substance ID:
EC Number:
208-250-4
Beilstein/REAXYS Number:
99163
MDL number:
InChI key
YJGVMLPVUAXIQN-XVVDYKMHSA-N
InChI
1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19-,20-/m0/s1
SMILES string
COc1cc(cc(OC)c1OC)[C@H]2C3C(COC3=O)[C@@H](O)c4cc5OCOc5cc24
assay
≥98%
form
powder
mp
183-184 °C (lit.)
storage temp.
2-8°C
Quality Level
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Application
Podophyllotoxin has been used as a reference compound for evaluating the cytotoxicity in VERO cells. It has also been used as a reference standard in high-performance liquid chromatography (HPLC).
Biochem/physiol Actions
Inhibits microtubule assembly; antineoplastic.
Podophyllotoxin is a naturally occurring lignan obtained from resin podophyllin present in the genus Podophyllum. It exhibits antiviral and antimitotic properties. Podophyllotoxin may be used to treat anogenital warts in children and dermatological conditions caused by psoriasis vulgaris. It may also be used as a therapeutic agent to treat genital tumors, Wilms tumors, lung cancer, and lymphomas.
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
此项目有
Ronald W Brown et al.
RSC medicinal chemistry, 11(12), 1413-1422 (2021-06-08)
African sleeping sickness is a potentially fatal neglected disease affecting sub-Saharan Africa. High-throughput screening identified the thiazolyl-benzothiophenamide 1 to be active against the causative parasite, Trypanosoma brucei. This work establishes structure-activity relationships of 1, guiding the design of second generation
Diterpenoids as potential anti-malarial compounds from Andrographis paniculata
Dwivedi M, et al.
Beni-Suef University Journal of Basic and Applied Sciences, 10(1), 1-16 (2021)
Podophyllotoxin: current perspectives
Qian L, et al.
Current Bioactive Compounds, 3(1), 37-66 (2007)
HPLC-Based Activity Profiling for Antiprotozoal Compounds in Croton gratissimus and Cuscuta hyalina.
Abdelhalim Babiker Mahmoud et al.
Frontiers in pharmacology, 11, 1246-1246 (2020-09-15)
In a screening of Sudanese medicinal plants for antiprotozoal activity, the chloroform fractions obtained by liquid-liquid partitioning from ethanolic extracts of fruits of Croton gratissimus var. gratissimus and stems of Cuscuta hyalina Roth ex Schult. exhibited in vitro activity against
High-elevation cultivation increases anti-cancer podophyllotoxin accumulation in Podophyllum hexandrum
Li M, et al.
Industrial Crops and Products, 121, 33-344 (2018)
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