P4404
多聚鸟苷酸 钾盐
≥95% (TLC), enzyme from (synthesis), lyophilized powder
别名:
聚(G) 钾盐
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关于此项目
Assay:
≥95% (TLC)
Biological source:
enzyme from (synthesis)
Form:
lyophilized powder
Solubility:
water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to light yellow
Storage temp.:
−20°C
产品名称
多聚鸟苷酸 钾盐, lyophilized powder
biological source
enzyme from (synthesis)
assay
≥95% (TLC)
form
lyophilized powder
quality
≤5% free nucleotides
solubility
water: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to light yellow
storage temp.
−20°C
Quality Level
General description
多聚鸟苷酸形成4股螺旋结构。它在嗜热栖热菌(Thermus thermophilus)多聚核苷酸磷酸化酶催化下、以鸟苷二磷酸(GDP)为底物合成。
Application
多聚鸟苷酸钾盐已用于：
- 在内化研究中作为表面神经纤毛蛋白-1(NRP1)的配体
- 用于伏安法研究其与三取代和双取代三唑连接苯基衍生物CL41、CL42和CL2r50之间的相互作用
- 作为人工合成的多聚核苷酸，用于琼脂糖凝胶电泳分析
聚鸟苷酸（PolyG）可用于研究电离辐射对G-四链体结构的形成和稳定性的影响，还可用作鸟苷电子激发（振动光谱）物理化学研究的目标分子。
Biochem/physiol Actions
多聚鸟苷酸可作为清道夫受体的配体，降低内皮细胞表面神经纤毛蛋白-1表达。
Preparation Note
用多核苷酸磷酸化酶由GDP制备而得。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Masashi Narazaki et al.
Blood, 116(16), 3099-3107 (2010-07-08)
Ligand interaction with cognate cell-surface receptor often promotes receptor internalization, protecting cells from prolonged or excessive signaling from extracellular ligands. Compounds that induce internalization of surface receptors prevent ligand binding to cognate cell-surface receptors serving as inhibitors. Here, we show
Picosecond infrared probing of the vibrational spectra of transients formed upon UV excitation of stacked G-tetrad structures.
McGovern DA, Quinn S, Doorley GW, et al.
Chemical Communications (Cambridge, England), 28, 5158-5160 (2007)
Venugopal Karunakaran et al.
Journal of the American Chemical Society, 131(16), 5839-5850 (2009-04-04)
Guanosine monophosphate (GMP) in aqueous solutions has been studied with femtosecond broad-band transient absorption spectroscopy and by quantum-mechanical calculations. The sample was excited at 267 or 287 nm and probed between 270 and 1000 nm with 100 fs resolution, for
Y Kikuchi et al.
Biochimica et biophysica acta, 476(4), 287-294 (1977-06-17)
Polyguanylic acid (poly(G)) was synthesized from GDP in a yield of 60-75% by Thermus thermophilus polynucleotide phosphorylase (polyribonucleotide: orthophosphate nucleotidyltransferase, EC 2.7.7.8) at 70 degrees C, pH 8.5 in the presence of Mg2+. The yield was dependent on the ratio
Principles of nucleic acid structure
Neidle, Stephen
Principles of nucleic acid structure (2018)
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