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一般描述
多聚鸟苷酸形成4股螺旋结构。它在嗜热栖热菌(Thermus thermophilus)多聚核苷酸磷酸化酶催化下、以鸟苷二磷酸(GDP)为底物合成。
应用
多聚鸟苷酸钾盐已用于：
- 在内化研究中作为表面神经纤毛蛋白-1(NRP1)的配体
- 用于伏安法研究其与三取代和双取代三唑连接苯基衍生物CL41、CL42和CL2r50之间的相互作用
- 作为人工合成的多聚核苷酸，用于琼脂糖凝胶电泳分析
聚鸟苷酸（PolyG）可用于研究电离辐射对G-四链体结构的形成和稳定性的影响，还可用作鸟苷电子激发（振动光谱）物理化学研究的目标分子。
生化/生理作用
多聚鸟苷酸可作为清道夫受体的配体，降低内皮细胞表面神经纤毛蛋白-1表达。
制备说明
用多核苷酸磷酸化酶由GDP制备而得。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Nathan R Deleault et al.
The Journal of biological chemistry, 280(29), 26873-26879 (2005-05-27)
Little is currently known about the biochemical mechanism by which induced prion protein (PrP) conformational change occurs during mammalian prion propagation. In this study, we describe the reconstitution of PrPres amplification in vitro using partially purified and synthetic components. Overnight
Masashi Narazaki et al.
Blood, 116(16), 3099-3107 (2010-07-08)
Ligand interaction with cognate cell-surface receptor often promotes receptor internalization, protecting cells from prolonged or excessive signaling from extracellular ligands. Compounds that induce internalization of surface receptors prevent ligand binding to cognate cell-surface receptors serving as inhibitors. Here, we show
Picosecond infrared probing of the vibrational spectra of transients formed upon UV excitation of stacked G-tetrad structures.
McGovern DA, Quinn S, Doorley GW, et al.
Chemical Communications (Cambridge, England), 28, 5158-5160 (2007)
Venugopal Karunakaran et al.
Journal of the American Chemical Society, 131(16), 5839-5850 (2009-04-04)
Guanosine monophosphate (GMP) in aqueous solutions has been studied with femtosecond broad-band transient absorption spectroscopy and by quantum-mechanical calculations. The sample was excited at 267 or 287 nm and probed between 270 and 1000 nm with 100 fs resolution, for
Y Kikuchi et al.
Biochimica et biophysica acta, 476(4), 287-294 (1977-06-17)
Polyguanylic acid (poly(G)) was synthesized from GDP in a yield of 60-75% by Thermus thermophilus polynucleotide phosphorylase (polyribonucleotide: orthophosphate nucleotidyltransferase, EC 2.7.7.8) at 70 degrees C, pH 8.5 in the presence of Mg2+. The yield was dependent on the ratio
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