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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
rat
技术
western blot: 1:200 using KCNQ2 transfected HEK-293 cells
UniProt登记号
储存温度
−20°C
基因信息
human ... KCNQ2(3785)
mouse ... Kcnq2(16536)
rat ... Kcnq2(170848)
一般描述
Potassium voltage-gated channel subfamily Q member 2 (KCNQ2) is one of the five isoforms of KCNQ channels. It is expressed in the central and peripheral nervous system.
特异性
The antibody does not cross-react with KCNQ3 or other QKT proteins. There are at least 9 splice variants of rat KCNQ2. The antibody recognizes all splice variants except B and G.
免疫原
peptide corresponding to amino acid residues 578-593 of rat KCNQ2. This epitope is identical in mouse and highly homologous in human (15/16 residues identical).
生化/生理作用
Potassium voltage-gated channel subfamily Q member 2 (KCNQ2) acts as a mediator of sub-threshold activated muscarinic-regulated K+ current (M-current). It modulates neuronal excitability. Mutations in the gene encoding this protein have been associated with benign neonatal familial convulsions.
外形
Lyophilized at ~0.7 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.025% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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法规信息
新产品
Activation of peripheral KCNQ channels relieves gout pain.
Zheng Y
Pain (2015)
Involvement of KCNQ2 subunits in [3H]dopamine release triggered by depolarization and pre-synaptic muscarinic receptor activation from rat striatal synaptosomes
Maria M
Journal of Neurochemistry (2007)
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