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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to yellow
溶解性
H2O: 22 mg/mL
SMILES字符串
Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1
InChI
1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2
InChI key
YCALIZUKAFUQCH-UHFFFAOYSA-N
应用
PJ-34盐酸盐水合物用于：
- 作为聚（ADP-核糖）聚合酶(PARP)抑制剂1，测试PAPR1对大鼠神经性疼痛的作用
- 作为蛋白质提取缓冲液的组分，可视化各种细胞样本中中PARylated蛋白质的高分子量涂片
- 作为小鼠MLE-12上皮细胞系的PARP抑制剂
生化/生理作用
PJ-34是一种原型聚（ADP-核糖）聚合酶1 (PARP-1)抑制剂。
PJ-34是一种强效聚(ADP-核糖)聚合酶（PARP）抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
G E Abdelkarim et al.
International journal of molecular medicine, 7(3), 255-260 (2001-02-17)
Focal cerebral ischemia activates the nuclear protein poly(ADP-ribose) polymerase (PARP) by single DNA strand breaks which leads to energy depletion and cell necrosis. Deletion or inhibition of PARP protects against ischemic brain injury. Here we examined the neuroprotective effect of
Yan Gao et al.
Brain, behavior, and immunity, 88, 482-496 (2020-04-14)
Emerging evidence has implicated poly-(ADP-ribose) polymerase 1 (PARP-1), a transcriptional coregulator, in a variety of inflammatory diseases. In the current study, the role of PARP-1 in neuropathic pain and the underlying mechanisms were investigated. Neuropathic pain was determined by assessing
Hai-yan Li et al.
Acta pharmacologica Sinica, 35(4), 496-503 (2014-03-19)
Daidzein (4',7-dihydroxyisoflavone) is an isoflavone exiting in many herbs that has shown anti-inflammation activity. The aim of this study was to investigate the mechanism underlying its anti-inflammatory action in murine lung epithelial cells. C57BL/6 mice were intranasally exposed to TNF-α
Garcia Soriano F et al.
Nature medicine, 7(1), 108-113 (2001-01-03)
Diabetic patients frequently suffer from retinopathy, nephropathy, neuropathy and accelerated atherosclerosis. The loss of endothelial function precedes these vascular alterations. Here we report that activation of poly(ADP-ribose) polymerase (PARP) is an important factor in the pathogenesis of endothelial dysfunction in
Hengmei Zhu et al.
Diabetes, metabolic syndrome and obesity : targets and therapy, 14, 355-366 (2021-02-04)
Diabetic nephropathy (DN) is a metabolic disorder characterized by the accumulation of extracellular matrix (ECM). This study aims to investigate whether exists an interplay between poly (ADP-ribose) polymerase 1 (PARP-1) and sirtuin 1 (SIRT-1) in DN via AMP-activated protein kinase
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