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P4365

PJ-34 盐酸盐 水合物

≥98% (HPLC), powder

别名:

PARP抑制剂VIII, PJ 34 HCl, N-(6-氧代-5,6-二氢菲啶-2-基)-(N,N-二甲基氨基)乙酰胺 盐酸盐

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关于此项目

经验公式（希尔记法）:
C17H17N3O2 · HCl · xH2O
化学文摘社编号:
344458-15-7
分子量:
331.80 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24898531
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
Storage condition:
desiccated
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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to yellow

solubility

H2O: 22 mg/mL

SMILES string

Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1

InChI

1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2

InChI key

YCALIZUKAFUQCH-UHFFFAOYSA-N

Application

PJ-34盐酸盐水合物用于：
  • 作为聚（ADP-核糖）聚合酶(PARP)抑制剂1，测试PAPR1对大鼠神经性疼痛的作用
  • 作为蛋白质提取缓冲液的组分，可视化各种细胞样本中中PARylated蛋白质的高分子量涂片
  • 作为小鼠MLE-12上皮细胞系的PARP抑制剂

Biochem/physiol Actions

PJ-34是一种原型聚（ADP-核糖）聚合酶1 (PARP-1)抑制剂。
PJ-34是一种强效聚(ADP-核糖)聚合酶（PARP）抑制剂。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000174914
0000174914
0000113076
0000069854
0000015950

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Garcia Soriano F et al.
Nature medicine, 7(1), 108-113 (2001-01-03)
Diabetic patients frequently suffer from retinopathy, nephropathy, neuropathy and accelerated atherosclerosis. The loss of endothelial function precedes these vascular alterations. Here we report that activation of poly(ADP-ribose) polymerase (PARP) is an important factor in the pathogenesis of endothelial dysfunction in
Hai-yan Li et al.
Acta pharmacologica Sinica, 35(4), 496-503 (2014-03-19)
Daidzein (4',7-dihydroxyisoflavone) is an isoflavone exiting in many herbs that has shown anti-inflammation activity. The aim of this study was to investigate the mechanism underlying its anti-inflammatory action in murine lung epithelial cells. C57BL/6 mice were intranasally exposed to TNF-α
Yan Gao et al.
Brain, behavior, and immunity, 88, 482-496 (2020-04-14)
Emerging evidence has implicated poly-(ADP-ribose) polymerase 1 (PARP-1), a transcriptional coregulator, in a variety of inflammatory diseases. In the current study, the role of PARP-1 in neuropathic pain and the underlying mechanisms were investigated. Neuropathic pain was determined by assessing
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货号GTIN
P4365-5MG04061834374428