所有图片(1)
About This Item
线性分子式:
C16H18N2OS·HBr
CAS号:
分子量:
367.30
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
检测方案
≥95% (HPLC)
形式
powder
储存条件
protect from light
颜色
off-white
mp
192.1-192.5 °C (lit.)
溶解性
DMSO: 20 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
Br[H].Cc1ccc(cc1)C(=O)CN2C(=N)SC3=C2CCCC3
InChI
1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H
InChI key
HAGVCKULCLQGRF-UHFFFAOYSA-N
应用
吡菲他林-α已用于：
- 研究特异性 p53 抑制剂对短暂性全脑缺血 (tGCI) 后 p53 上调的凋亡调节因子 (PUMA) 表达的影响
- 作为 p53 抑制剂处理 PA1 细胞
- 作为肿瘤蛋白 p53 (TRP53) 抑制剂，处理小鼠肺上皮-12 (MLE-12) 细胞
生化/生理作用
吡菲他林-α是 p53 介导的细胞凋亡和 p53 依赖性基因转录如细胞周期蛋白 G、p21/waf1 和 mdm2 表达的可逆性抑制剂。吡菲他林-α在遗传毒性应激（如 UV 照射）和细胞毒性化合物（包括多柔比星、依托泊苷、紫杉醇和胞嘧啶-β-D-阿拉伯呋喃糖苷）处理后增强细胞存活。吡菲他林-α保护小鼠免受致死性全身 γ-辐射，且不增加癌症发病率。这种保护作用在 p53 缺失的小鼠或 p53 基因显性负突变体表达的细胞中没有观察到。p53 缺陷细胞系中 p53 的瞬时表达赋予保护作用。
特点和优势
该化合物是细胞凋亡研究的特色产品。点击此处发现更多特色细胞凋亡产品。在sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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