生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
ascites fluid
抗体产品类型
primary antibodies
克隆
DCS-100, monoclonal
分子量
antigen 19 kDa
包含
15 mM sodium azide
种属反应性
human
技术
immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1:1,000 using a cultured human tumor cell line extract
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CDKN2D(1032)
一般描述
Cyclin dependent kinase inhibitor 2D (CDKN2D), also referred to as p19INK4d, is part of the inhibitors of cyclin-dependent kinases (INK4) family. It consists of 166 amino acids and five ankyrin-like repeats that aid in protein-protein interactions. The gene encoding this protein is localized on human chromosome 19p13.
特异性
Shows no cross-reactivity with other closely related Cdk inhibitors, such as p15INK4b, p16INK4a and p18INK4c.
免疫原
recombinant human p19INK4d.
应用
Monoclonal Anti-p19INK4d antibody produced in mouse has been used in microarray.
生化/生理作用
Cyclin dependent kinase inhibitor 2D (CDKN2D) functions as a modulator of the cell cycle and has a role in DNA damage response. It acts as a chromatin accessibility factor. The protein associates with cyclin-dependent kinase 4 and 6 and inhibits their kinase activity.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Further intracellular proteins and signaling pathways regulated by angiotensin-(1?7) in human endothelial cells
Christian Meinert
Data in Brief (2017)
Nuclear translocation of p19INK4d in response to oxidative DNA damage promotes chromatin relaxation.
Sonzogni SV
Molecular and Cellular Biochemistry (2015)
Nuclear translocation of p19INK4d in response to oxidative DNA damage promotes chromatin relaxation.
Anna F
Cancer Biology & Therapy (2013)
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