生物来源
human
质量水平
重组
expressed in E. coli
检测方案
≥97% (SDS-PAGE)
形式
lyophilized powder
效能
1.0-3.0 ng/mL EC50
质量
endotoxin tested
分子量
24.3 kDa
包装
pkg of 10 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
≤1 EU/μg
UniProt登记号
储存温度
−20°C
基因信息
human ... PDGFB(5155)
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一般描述
Platelet-Derived Growth Factor (PDGF), a cationic polypeptide, is an important serum mitogen predominantly found in cells of mesenchymal origin. PDGF is mapped to human chromosome 7p22.3 and is expressed in smooth muscle cells, endothelial cells and macrophages. PDGF exists as hetero and homodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD.
应用
Platelet-Derived Growth Factor-BB human has been used in induction of DNA synthesis and proliferation in low-concentration serum.
生化/生理作用
Platelet-derived growth factor (PDGF) is a potent chemoattractant and activator of neutrophils, monocytes, and fibroblasts. PDGF elicits multifunctional actions in a variety of cells. It is mitogenic to mesoderm-derived cells, such as dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. PDGF-BB isomer is highly expressed in tumor, mediating oncogenic pericyte recruitment and is is a key regulator of angiogenesis. PDGF-BB controls bone homeostasis, repair and regeneration. It increases the synthesis of phospholipids, cholesterol esters, glycogen and prostaglandins and modulates LDL receptor binding.
其他说明
Dimer of the B chain of human PDGF.
外形
Lyophilized from a 0.2 μm filtered solution.
分析说明
The biological activity is measured by the dose-dependent stimulation of thymidine uptake in BALB/c 3T3 cells.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Growth factors in the treatment of early osteoarthritis
Civinini R, et al.
Clinical Cases in Mineral and Bone Metabolism : The Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 10.1, 26-26 (2013)
Overexpression of platelet-derived growth factor-BB increases tumor pericyte content via stromal-derived factor-1a/CXCR4 axis
Song N, et al.
Cancer Research, 69.15, 6057-6064 (2009)
A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair.
Schmidt MB, et al.
Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society, 14.5, 403-412 (2006)
The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals
Zhang XA, et al.
Oncotarget, 7(22), 33340-33349 (2016)
The role of growth factors in wound healing
David L, et al.
The Surgical Clinics of North America, 77.3, 575-586 (1997)
商品
Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.
血小板衍生生长因子是在哺乳动物血清中发现的主要有丝分裂原，在血栓形成过程中从血小板释放。
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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