P4236
Cyclic Pifithrin-α hydrobromide
≥98% (HPLC)
别名:
2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide, Cyclic PFT-α hydrobromide, Pifithrin-α, cyclic, QB102
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所有图片(1)
About This Item
经验公式（希尔记法）:
C16H16N2S · HBr
CAS号:
分子量:
349.29
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
溶解性
DMSO: 20 mg/mL
运输
dry ice
储存温度
−20°C
SMILES字符串
Br[H].Cc1ccc(cc1)-c2cn3c4CCCCc4sc3n2
InChI
1S/C16H16N2S.BrH/c1-11-6-8-12(9-7-11)13-10-18-14-4-2-3-5-15(14)19-16(18)17-13;/h6-10H,2-5H2,1H3;1H
InChI key
SGNCOAOESGSEOP-UHFFFAOYSA-N
应用
Cyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells.
生化/生理作用
A stable analog of Pifithrin-α (Product Code P4359) with similar biological activities and lower cellular toxicity.
包装
Protect from light.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation
Murphy P J M, et al.
The Journal of Biological Chemistry, 279(29), 30195-30201 (2004)
p53 mediates cigarette smoke-induced apoptosis of pulmonary endothelial cells: inhibitory effects of macrophage migration inhibitor factor
Damico R, et al.
American Journal of Respiratory Cell and Molecular Biology, 44(3), 323-332 (2011)
Rachel Damico et al.
American journal of respiratory cell and molecular biology, 44(3), 323-332 (2010-05-08)
Exposure to cigarette smoke (CS) is the most common cause of emphysema, a debilitating pulmonary disease histopathologically characterized by the irreversible destruction of lung architecture. Mounting evidence links enhanced endothelial apoptosis causally to the development of emphysema. However, the molecular
Tatiana Cardinal et al.
PLoS genetics, 16(9), e1009008-e1009008 (2020-09-09)
Hirschsprung disease (HSCR) is a complex genetic disorder of neural crest development resulting in incomplete formation of the enteric nervous system (ENS). This life-threatening neurocristopathy affects 1/5000 live births, with a currently unexplained male-biased ratio. To address this lack of
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