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Merck
CN

P4157

Sigma-Aldrich

苯丙氨酸-精氨酸 β-萘胺 二盐酸盐

cathepsin substrate

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别名:
PAβN
经验公式(希尔记法):
C25H30N6O2 · 2HCl
分子量:
519.47
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32

质量水平

检测方案

≥98% (TLC)

形式

powder

溶解性

water: 50 mg/mL, clear, colorless to faintly yellow

储存温度

−20°C

SMILES字符串

Cl.NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3ccccc3c2

InChI

1S/C25H30N6O2.ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);1H

InChI key

ZMTAZQYLEGNUTJ-UHFFFAOYSA-N

一般描述

Phe-Arg β-萘酰胺,一种拟肽化合物, 是一种外排泵抑制剂(EPI)。它可作用于革兰氏阴性细菌的主要多药耐药性外向转运蛋白。Phe-Arg-萘酰胺可在铜绿假单胞菌中降低氟喹诺酮类药物的耐药性。

应用

Phe-Arg-萘酰胺二盐酸盐用于评估外排泵对抗菌素耐药性的贡献。在存在外排泵抑制剂的条件下,它还用于最小抑菌浓度测试。

包装

无底玻璃瓶。内含物在插入的融合锥体内。

底物

二肽基氨肽酶I(组织蛋白酶C)的底物。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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