P4124
Anti-PM/Scl-100 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
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别名:
Anti-Autoantigen PM/Scl 2, Anti-EXOSC10, Anti-Exsosome Component 10, Anti-P100, Anti-PMSCL Autoantigen, 100-KD, Anti-PMSCL2, Anti-Polymyositis-scleroderma Overlap Syndrome Associated Autoantigen, Anti-Polymyositis/scleroderma Autoantigen 2, Anti-Polymyositis/scleroderma Autoantigen, 100 kDa
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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen ~100 kDa
种属反应性
human, rat, mouse
浓度
~1.0 mg/mL
技术
indirect immunofluorescence: 1-2 μg/mL using rat NRK and mouse NIH3T3 cells
western blot (chemiluminescent): 1-2 μg/mL using nuclear exracts to HeLa human epithelioid carcinoma cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... EXOSC10(5394)
mouse ... Exosc10(50912)
一般描述
PM/SCL-100 (human exosome) is also known as RRP6, EXOSC10 (exosome component 10). It is a heterogeneous autoantibody that is located on human chromosome 1p36. In mouse, EXOSC10 is located on XY body.
免疫原
synthetic peptide corresponding to amino acid residues 231-245 of human PM/Scl-100 with an N-terminal added cysteine, conjugated to KLH. The corresponding sequence is identical in both rat and mouse PM/Scl-100.
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)
生化/生理作用
PM/SCL-100 (human exosome) participates in ribosome biogenesis, snoRNA (small nucleolar RNAs)processing, surveillance and degradation of nonfunctional transcripts. It is essential for the production of 40S subunit and to maintain global translation. EXOSC10 participates in mitotic cell division. In mouse, Exosc10 is required for spermatogonial proliferation and early embryogenesis.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients.
Hanke K et al
Arthritis Research & Therapy, 11(1), R22-R22 (2009)
Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.
Knight JR et al
RNA, 22(4), 623-635 (2016)
Activities of human RRP6 and structure of the human RRP6 catalytic domain.
Januszyk K, et al.
RNA, 17(8), 1566-1577 (2011)
Differential expression between human dermal papilla cells from balding and non-balding scalps reveals new candidate genes for androgenetic alopecia.
Chew EG, et al.
The Journal of Investigative Dermatology, 136(8), 1559-1567 (2016)
EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis.
Jamin SP, et al.
Scientific Reports, 7(1), 15065-15065 (2017)
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