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安全信息

P4124

Sigma-Aldrich

Anti-PM/Scl-100 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

别名:

Anti-Autoantigen PM/Scl 2, Anti-EXOSC10, Anti-Exsosome Component 10, Anti-P100, Anti-PMSCL Autoantigen, 100-KD, Anti-PMSCL2, Anti-Polymyositis-scleroderma Overlap Syndrome Associated Autoantigen, Anti-Polymyositis/scleroderma Autoantigen 2, Anti-Polymyositis/scleroderma Autoantigen, 100 kDa

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About This Item

MDL编号:
MFCD08705502
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

rabbit

质量水平

200

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen ~100 kDa

种属反应性

human, rat, mouse

浓度

~1.0 mg/mL

技术

indirect immunofluorescence: 1-2 μg/mL using rat NRK and mouse NIH3T3 cells
western blot (chemiluminescent): 1-2 μg/mL using nuclear exracts to HeLa human epithelioid carcinoma cells

UniProt登记号

Q01780

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... EXOSC10(5394)
mouse ... Exosc10(50912)

相关类别

一般描述

PM/SCL-100 (human exosome) is also known as RRP6, EXOSC10 (exosome component 10). It is a heterogeneous autoantibody that is located on human chromosome 1p36. In mouse, EXOSC10 is located on XY body.

免疫原

synthetic peptide corresponding to amino acid residues 231-245 of human PM/Scl-100 with an N-terminal added cysteine, conjugated to KLH. The corresponding sequence is identical in both rat and mouse PM/Scl-100.

应用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunofluorescence (1 paper)
Western Blotting (1 paper)

生化/生理作用

PM/SCL-100 (human exosome) participates in ribosome biogenesis, snoRNA (small nucleolar RNAs)processing, surveillance and degradation of nonfunctional transcripts. It is essential for the production of 40S subunit and to maintain global translation. EXOSC10 participates in mitotic cell division. In mouse, Exosc10 is required for spermatogonial proliferation and early embryogenesis.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000363241
0000130367
0000086428
0000363241
0000130367

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Differential expression between human dermal papilla cells from balding and non-balding scalps reveals new candidate genes for androgenetic alopecia.
Chew EG, et al.
The Journal of Investigative Dermatology, 136(8), 1559-1567 (2016)
Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients.
Hanke K et al
Arthritis Research & Therapy, 11(1), R22-R22 (2009)
Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.
Knight JR et al
RNA, 22(4), 623-635 (2016)
EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis.
Jamin SP, et al.
Scientific Reports, 7(1), 15065-15065 (2017)
Activities of human RRP6 and structure of the human RRP6 catalytic domain.
Januszyk K, et al.
RNA, 17(8), 1566-1577 (2011)

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