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安全信息

P4119

Sigma-Aldrich

多粘菌素 B 硫酸盐

Biotechnology Performance Certified

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About This Item

经验公式（希尔记法）:
C55H96N16O13 · 2H2SO4
CAS号:
1405-20-5
分子量:
1385.61
EC 号:
215-774-7
MDL编号:
MFCD00131991
UNSPSC代码:
41116107

等级

Biotechnology Performance Certified

表单

powder

技术

cell culture | mammalian: suitable

杂质

endotoxin, tested

溶解性

H2O: soluble 50 mg/mL

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
fungi

作用机制

cell membrane | interferes

储存温度

2-8°C

SMILES字符串

O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

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一般描述

Chemical structure: peptide

应用

Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa †. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

生化/生理作用

作用机制：多粘菌素B硫酸盐结合到细菌脂多糖的脂质部分†上，通过诱导足够大的孔来破坏细胞质膜，使核苷酸泄漏到细菌的细胞壁中。 这可破环细胞质膜的半透性。

抗菌谱：对大多数革兰氏阴性杆菌，包括 大肠杆菌 ，真菌和革兰氏阳性菌都有杀菌作用。

注意

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.

制备说明

Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol. This product is biotechnology performance certified.

其他说明

10mu,25mu,50mu
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCBJ2750V
BCBG6353V
BCBG1861V
BCBD8823V
BCBC8942V

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Andrea Giacometti et al.
The Journal of antimicrobial chemotherapy, 49(1), 193-196 (2001-12-26)
The efficacy of two polymyxin-like peptides, KFFKFFKFF and IKFLKFLKFL, alone and combined with levofloxacin, was investigated in a rat model of septic shock. Rats were given an ip injection of 2 x 10(10) cfu of Escherichia coli and randomized to
Michael Hogardt et al.
The Journal of antimicrobial chemotherapy, 54(6), 1057-1061 (2004-10-29)
With their potent activity against Gram-negative bacteria, the polymyxins are important alternative antibiotics for cystic fibrosis (CF) patients. A retrospective evaluation of polymyxin activity against 6001 Pseudomonas aeruginosa, 150 Achromobacter xylosoxidans and 506 Stenotrophomonas maltophilia CF isolates was initiated. In
Barbara Valentinis et al.
The Journal of biological chemistry, 280(14), 14264-14271 (2005-01-27)
Polymyxin B is a lipopolysaccharide binding antibiotic used to inactivate potential lipopolysaccharide contaminations when evaluating the activity of different agents on innate immune cells. We report that polymyxin B is able to induce directly in monocyte-derived human dendritic cells (DCs)
Hiroyuki Hirasawa et al.
Blood purification, 34(2), 164-170 (2012-10-26)
Since the introduction of the new pathophysiological concept of pathogen-associated molecular patterns (PAMPS) and alarmins, endotoxin has been recognized as only one of the PAMPS. It is widely accepted that hypercytokinemia plays a pivotal role in the pathophysiology of sepsis.
H Deborah Chen et al.
PLoS genetics, 8(12), e1003060-e1003060 (2013-01-10)
Changes in gene regulatory circuits often give rise to phenotypic differences among closely related organisms. In bacteria, these changes can result from alterations in the ancestral genome and/or be brought about by genes acquired by horizontal transfer. Here, we identify
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