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产品名称
Platelet-Derived Growth Factor-BB 来源于大鼠, PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
重组
expressed in E. coli
质量水平
表单
lyophilized powder
效能
1.62 ng/mL EC50
质量
endotoxin tested
分子量
~30 kDa
包装
pkg of 5x50 μg
pkg of 50 μg
储存条件
avoid repeated freeze/thaw cycles
技术
cell culture | mammalian: suitable
杂质
≤1 EU/μg
UniProt登记号
储存温度
−20°C
基因信息
rat ... Pdgfb(24628)
一般描述
Platelet-derived growth factor (PDGF) is a 30 kDa cationic polypeptide and consists of two disulphide linked chains A and B. PDGF is expressed as hetero and homodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD.
应用
Platelet-Derived Growth Factor-BB from rat has been used as a growth supplement in mouse embryonic fibroblast culture, motoneuron-muscle co-culture and adult spinal cord neurons culture.
生化/生理作用
Platelet-derived growth factor (PDGF) elicits multifunctional actions with a variety of cells. It is mitogenic to mesoderm-derived cells, such as dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells, and chondrocytes. PDGF is a potent chemoattractant and activator of neutrophils, monocytes, and fibroblasts. PDGF activates smooth muscle relocalization and multiplication. PDGF mediated increased smooth muscle muscle proliferation might be associated with gene regulation. It increases the synthesis of phospholipids, cholesterol esters, glycogen and prostaglandins, and modulates LDL (low density lipoprotein) receptor binding.
其他说明
Dimer of the B chain of rat PDGF.
外形
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 2.5 mg bovine serum albumin.
分析说明
The biological activity is measured by its ability to stimulate 3H-thymidine incorporation in quiescent NR6R-3T3 fibroblasts.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Yuhan Chen et al.
Journal of inflammation research, 14, 2207-2223 (2021-06-04)
Activation of vascular adventitial fibroblasts (VAFs) upon vascular injury contributes greatly to the medial vascular smooth muscle cells (VSMCs) proliferation, migration and the subsequent neointima formation. A number of factors including fibroblast growth factors (FGFs) have been shown to control
Role of platelets in the development of atherosclerosis.
Quintana L, et al.
Tissue Engineering: Part A, 15.1, 45-54 (2008)
Skeletal muscle tissue engineering: A maturation model promoting long-term survival of myotubes, structural development of the excitation?contraction coupling apparatus and neonatal myosin heavy chain expression.
Das M, et al.
Biomaterials, 30.29, 5392-5402 (2009)
Eileen M Bauer et al.
PloS one, 9(5), e96720-e96720 (2014-05-20)
Pulmonary hypertension (PH) is a progressive and fatal disease with no cure. Vascular remodeling in PH involves intraluminal growth of endothelial and smooth muscle cells, leading to obliterative vascular lesions. Cell growth in these lesions is quasi-neoplastic, with evidence of
Platelet-Derived Growth Factor?BB Transactivates the Fibroblast Growth Factor Receptor to Induce Proliferation in Human Smooth Muscle Cells.
Millette E, et al.
Trends in Cardiovascular Medicine, 16.1, 25-28 (2006)
商品
Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.
血小板衍生生长因子是在哺乳动物血清中发现的主要有丝分裂原，在血栓形成过程中从血小板释放。
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