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描述
enzyme inhibitor
质量水平
方案
≥99% (HPLC)
表单
powder
mp
218-220 °C (lit.)
溶解性
10% NH3: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
SMILES字符串
CCCC1=CC(=O)NC(=S)N1
InChI
1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
InChI key
KNAHARQHSZJURB-UHFFFAOYSA-N
基因信息
human ... DIO1(1733) , TPO(7173)
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一般描述
6-丙基-2-硫尿嘧啶或6-n-丙基硫尿嘧啶（PROP，或丙硫氧嘧啶PTU）是一种带苦味物质。
应用
6-丙基-2-硫尿嘧啶(PROP)已用于浸渍尝味片，用于研究限定人样品组中PROP品尝员的感官性状评价状态。 它已被用作筛选试剂，用于通过标签量值（labeled magnitude scale，LMS）测试味觉强度。
6-丙基-2-硫氧嘧啶是一种甲状腺抑制剂（甲状腺激素），可作为毛细管电泳、高效液相色谱（HPLC） 或气相色谱等甲状腺药物分离检测技术中的标准物质。
生化/生理作用
6-丙基-2-硫氧嘧啶（6-PTU）是D1碘甲状腺原氨酸脱碘酶的潜在抑制剂，参与了碘甲状腺原氨酸的脱碘作用。它是碘甲状腺原氨酸底物的非竞争性抑制剂。。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Carc. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil
Kuiper George GJM, et al.
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Adiposity in middle-aged women is associated with genetic taste blindness to 6-n-propylthiouracil
Goldstein G L, et al.
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