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Merck
CN

P3556

L-α-磷脂酰胆碱

egg yolk, Type XVI-E, ≥99% (TLC), lyophilized powder

别名:

1,2-二酰基-sn-甘油-3-胆碱磷酸, 3-sn-磷脂酰胆碱, L-α-卵磷脂, Azolectin, PC

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关于此项目

化学文摘社编号:
8002-43-5
UNSPSC Code:
51321705
NACRES:
NA.25
EC Number:
232-307-2
Beilstein/REAXYS Number:
5209585

主要文件

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产品名称

L-α-磷脂酰胆碱, egg yolk, Type XVI-E, ≥99% (TLC), lyophilized powder

SMILES string

[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI key

JLPULHDHAOZNQI-ZTIMHPMXSA-N

InChI

1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1

biological source

egg yolk

type

Type XVI-E

assay

≥99% (TLC)

form

lyophilized powder

functional group

phospholipid

lipid type

phosphoglycerides

shipped in

ambient

storage temp.

−20°C

Quality Level

200

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相关类别

Application

L-α-磷脂酰胆碱已：
  • 用于通过脂质体包裹的氯膦酸盐,形成用于Kupffer细胞去除的薄脂质膜
  • 作为γ-分泌酶体外测定所用的测定缓冲液组分
  • 用于制备5-脂氧合酶活性HPLC（高效液相色谱）测定的底物混合物

Biochem/physiol Actions

它还充当脂质信使/生物活性脂质来源，包括：溶血磷脂酰胆碱、二酰基甘油、磷脂酸、溶血磷脂酰胆碱、花生四烯酸和血小板活化因子。磷脂酰胆碱在肝脏中通过CDP-胆碱（胞苷二磷酸胆碱）途径产生。
脑磷脂脑中的主要结构磷脂，包含脂肪总量的约15%；主要局限于灰质。

General description

磷脂酰胆碱属于甘油糖脂类，含有胆碱头基。胆碱连接至与主链结合的脂肪酸酯的甘油上。它是真核生物中存在的主要磷脂。

Packaging

在氩气下包装

Preparation Note

制备参照 Singleton, W.S. 等人刊登于 J. Am. Oil Chem. Soc., 42, 53 (1965) 的工艺，并加以改进。

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000519309
0000519309
0000478236
0000478236
0000469230

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Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway
DeLong CJ, et al.
The Journal of Biological Chemistry, 274(42), 29683-29688 (1999)
Coactosin-like protein supports 5-lipoxygenase enzyme activity and up-regulates leukotriene A4 production
Rakonjac M, et al.
Proceedings of the National Academy of Sciences of the USA, 103(35), 13150-13155 (2006)
Lea M Hürlimann et al.
Antimicrobial agents and chemotherapy, 60(9), 5400-5411 (2016-07-07)
Nosocomial infections with Enterococcus faecalis are an emerging health problem. However, drug efflux pumps contributing to intrinsic drug resistance are poorly studied in this Gram-positive pathogen. In this study, we functionally investigated seven heterodimeric ABC transporters of E. faecalis that
FTIR-spectroscopic characterization of phosphocholine-headgroup model compounds
Pohle W, et al.
Journal of Molecular Structure, 563, 463-467 (2001)
Ireos Filipuzzi et al.
PLoS genetics, 12(11), e1006374-e1006374 (2016-11-18)
Invasive infections by fungal pathogens cause more deaths than malaria worldwide. We found the ergoline compound NGx04 in an antifungal screen, with selectivity over mammalian cells. High-resolution chemogenomics identified the lipid transfer protein Sec14p as the target of NGx04 and
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实验方案

LC/MS Analysis of Phospholipids in Milk on Asc

(soybean), ≥97%; L-α-Phosphatidylethanolamine from egg yolk, Type III, ≥97% (TLC), lyophilized powder; L-α-Phosphatidylcholine, from egg yolk, Type XVI-E, ≥99% (TLC), lyophilized powder; Sphingomyelin, from chicken egg yolk, ≥95%

相关内容

Product Information Sheet - P3556

Product Information Sheet

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