所有图片(2)
别名:
N-琥珀酰亚胺-3-(2-吡啶二硫代)丙酸酯, SPDP
经验公式（希尔记法）:
C12H12N2O4S2
CAS号:
分子量:
312.36
Beilstein:
1548137
EC 号:
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NC.07
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质量水平
检测方案
≥95%
形式
powder
反应适用性
reagent type: cross-linking reagent
mp
84-86 °C (lit.)
溶解性
acetone: 50 mg/mL
DMF: soluble
官能团
NHS ester
储存温度
−20°C
SMILES字符串
O=C(CCSSC1=NC=CC=C1)ON2C(CCC2=O)=O
InChI
1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
InChI key
JWDFQMWEFLOOED-UHFFFAOYSA-N
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一般描述
3-(2-吡啶基二硫代)丙酸 N-羟基琥珀酰亚胺酯（SPDP）是具有胺和巯基反应性的异源双功能交联剂。通常先在pH 7.5（6.5-8.5）的缓冲条件下通过酰胺键与含有伯胺的分子偶联。在pH 8.0（7.5-8.5）的缓冲条件下通过硫醇-二硫化物交换反应，与含有游离巯基的分子特异性二次偶联。此外，该试剂还可在初次偶联和还原接头后用作受保护的硫醇化试剂。它包含四个原子连接器。
应用
3-（2-吡啶基二硫代）丙酸N-羟基琥珀酰亚胺酯（SPDP）可用于制备酶免疫缀合物和半抗原载体分子偶联物。它已用于抗体缀合和作为蛋白质交联剂。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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