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方案
~99% (HPLC)
质量水平
表单
powder
颜色
white
溶解性
H2O: >2.0 mg/mL
创始人
Johnson & Johnson
SMILES字符串
Cl[H].Cl[H].NC(=O)C1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)N3CCCCC3
InChI
1S/C21H30FN3O2.2ClH/c22-18-8-6-17(7-9-18)19(26)5-4-12-24-15-10-21(11-16-24,20(23)27)25-13-2-1-3-14-25;;/h6-9H,1-5,10-16H2,(H2,23,27);2*1H
InChI key
BMXXSXQVMCXGJM-UHFFFAOYSA-N
应用
Pipamperone dihydrochloride may be used:
- as an internal standard in liquid chromatography with coulometric detection
- as an antipsychotic drugs to test its interaction with human ether-a-go-go-related gene (hERG) channel
- as an internal standard to spike human colostrum samples for reversed phase liquid chromatography- ultraviolet (LC-UV) analysis
生化/生理作用
D2 dopamine receptor antagonist; 5-HT2 serotonin receptor antagonist; antipsychotic.
Pipamperone, a butyrophenone derivative is a pharmacological chaperone and is a membrane-permeable dopamine receptor D4 (DRD4) antagonist. The affinity of pipamperone is higher for DRD4 and 5-hydroxytryptamine 2A receptor (5-HT2A) in comparison with DRD2. It may be useful therapeutic in treating behavioral disorders and psychomotor agitation symptoms.
特点和优势
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
M Schwaninger et al.
Clinical neuropharmacology, 21(6), 344-346 (1998-12-09)
Hypothermia is a potentially life-threatening emergency. This article examines the case of a 34-year-old, mentally retarded man who experienced three episodes of hypothermia during recurrent exposure to pipamperone. After the pipamperone dose was largely reduced, no further hypothermic episodes occurred.
K Nisijima et al.
Brain research, 890(1), 23-31 (2001-02-13)
The serotonin (5-HT) syndrome is the most serious side effect of antidepressants, and it often necessitates pharmacotherapy. In the present study, the efficacy of several drugs was evaluated in an animal model of the 5-HT syndrome. When 2 mg/kg of
Maria Addolorata Saracino et al.
Talanta, 81(4-5), 1547-1553 (2010-05-06)
A new analytical method, based on the use of liquid chromatography with coulometric detection, has been developed and applied to quantify risperidone and its main active metabolite 9-hydroxyrisperidone in human plasma and saliva. The analytes were separated on a reversed
Hypothermia in a patient with Alzheimer's disease receiving a combination therapy with risperidone and pipamperone.
Daniel Kamp et al.
Therapeutic advances in psychopharmacology, 6(1), 55-57 (2016-02-26)
J E Belgaied et al.
Journal of pharmaceutical and biomedical analysis, 30(4), 1417-1423 (2002-11-01)
The electrochemical reduction of pipamperone has been carried out in aqueous solution in KNO(3) (0.1 mol l(-1)) by differential-pulse polarography (DPP). Pipamperone exhibits a well-defined irreversible reduction peak at -1.3 V/ref. The influence of pH on the reduction of pipamperone
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