一般描述
前列腺特异性抗原（PSA）是含有237个氨基酸的26kDa单链糖蛋白，由定位于人19号染色体的激肽释放酶基因编码。它由人前列腺组织特异性表达，并且是一种在精液中表达的高度丰富的蛋白水解酶。
生化/生理作用
前列腺特异性抗原（PSA）是由前列腺组织特异性产生的由雄激素调节的丝氨酸蛋白酶，并且分泌至组织腔内。精液中的PSA可裂解精液凝固物中存在的精液凝集素。前列腺癌（PCa）患者的血清中总PSA水平升高。 PSA可作为PCa的潜在生物标志物。 血清蛋白酶抑制剂如α 1-抗胰凝乳蛋白酶（α 1-ACT）、α 2-巨球蛋白（α 2-M）和其他急性期蛋白，可与循环PSA形成不可逆复合物并阻碍PSA的蛋白水解活性。
前列腺特异性抗原（PSA）是腺激肽释放酶家族一种糖蛋白，其是一种具有胰凝乳蛋白酶样酶活性的丝氨酸蛋白酶。循环PSA以游离和蛋白酶抑制剂结合的形式存在。通过研究游离形式与抑制剂结合形式的比例可能有助于前列腺癌的诊断。
外形
溶于10mM Tris（pH 8.0），0.1％叠氮化钠溶液中
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Structure, function, and regulation of the enzyme activity of prostate-specific antigen.
Lilja H
World Journal of Urology, 11(4), 188-191 (1993)
D A Armbruster
Clinical chemistry, 39(2), 181-195 (1993-02-01)
Prostate-specific antigen (PSA) is a glycoprotein produced exclusively by prostatic tissue. PSA's absolute tissue specificity makes it valuable as a forensic marker and, more important, as a tumor marker for prostatic cancer. Prostatic cancer is prevalent in the older male
Qian Dang et al.
Analytical and bioanalytical chemistry, 408(25), 7067-7075 (2016-03-05)
A simple and sensitive electrogenerated chemiluminescence biosensor was developed to monitor matrix metalloproteinase 2 (MMP-2) by employing a specific peptide (CGPLGVRGK) as a molecular recognition substrate. Bis(2,2'-bipyridine)-4'-methyl-4-carboxybipyridine-ruthenium N-succinimidyl ester-bis(hexafluorophosphate) (Ru(bpy)2(mcbpy-O-Su-ester)(PF6)2 (Ru1) was used as ECL-emitting species and covalently labeled onto
Steven P Balk et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 21(2), 383-391 (2003-01-15)
Prostate-specific antigen (PSA) is an androgen-regulated serine protease produced by both prostate epithelial cells and prostate cancer (PCa) and is the most commonly used serum marker for cancer. It is a member of the tissue kallikrein family, some of the
Multiple forms of prostate-specific antigen in serum: differences in immunorecognition by monoclonal and polyclonal assays.
Zhou AM
Clinical Chemistry, 39(12), 2483-2491 (1993)
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