一般描述
研究领域：细胞信号传导。磷酸二酯酶I（PDEI）以PDE1A、PDE1B和PDE1C（2）三种亚型存在，位于中枢神经系统、心血管和其他器官中。
应用
响尾蛇毒液中的磷酸二酯酶 I 用于
- ：裂解 3′-5′ 端；RNA 寡聚体线性链中的核苷酸间键
- 作为磷酸二酯酶法中前体药物水解的模型
- 作为核苷酸剪切缓冲液中的组分
生化/生理作用
磷酸二酯酶I可破坏磷酸二酯键并催化各种核苷酸多磷酸盐的水解。 磷酸二酯酶I是由磷脂酰肌醇特异性磷脂酶C从真核质膜释放的。磷酸二酯酶I（PDEI）可以水解3′,5′-环磷酸腺苷（cAMP）和3′,5′-环磷酸鸟苷（cGMP）。它与Ca2+/钙调蛋白 （CaM）结合，从而刺激其催化活性。PDEI是一种生物治疗剂，用于治疗癌症、心脏病、肺病、代谢疾病、神经认知异常、肾病、内分泌异常和神经系统疾病。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Resp. Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
低风险生物材料
此项目有
Anatoly I Dragan et al.
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Otroshchenko VA and Vasilyeva NV
Reaction Kinetics and Catalysis Letters, 97(1), 151-156 (2009)
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