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Merck
CN

P3017

2-油酰-1-棕榈酰- 锡 -甘油基-3-磷酸胆碱

≥95.5% (GC), ≥98% (TLC)

别名:

1-十六烷2-（顺式-9-十八碳烯酰基）-sn-甘油-3-磷酸胆碱, 1-棕榈酰-2-油酰-sn-甘油-3-磷酸胆碱, 3-sn-磷脂酰胆碱，2-油酰-1-棕榈酰, L-β-油酰-γ-棕榈酰-α-磷脂, PC(16:0/18:1(9Z)), PC(16:0/18:1), PC(16:0/18:1w9), POPC

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关于此项目

经验公式（希尔记法）:
C42H82NO8P
化学文摘社编号:
26853-31-6
分子量:
760.08
UNSPSC Code:
12352211
NACRES:
NA.77
PubChem Substance ID:
24898382
EC Number:
248-056-7
Beilstein/REAXYS Number:
4173237
MDL number:
MFCD00043212

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产品名称

2-油酰-1-棕榈酰- 锡 -甘油基-3-磷酸胆碱, ≥95.5% (GC), ≥98% (TLC)

Quality Level

200

InChI key

WTJKGGKOPKCXLL-RYDYYDTQSA-N

InChI

1S/C42H82NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h20-21,40H,6-19,22-39H2,1-5H3/b21-20+/t40-/m1/s1

SMILES string

CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C\CCCCCCCC

assay

≥95.5% (GC)
≥98% (TLC)

form

powder

storage temp.

−20°C

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Application

2-油酰-1-棕榈锡-sn-甘油-3-磷酸胆碱已被用于：
  • 脂质体制备，用于植物样品中单半乳糖基二酰基甘油合成酶 (MGD1) 活性的脂质结合检测
  • 脂质体制备，用于融合人脐静脉内皮细胞 (HUVEC) ，以监控白细胞介素引起的凝血过程
  • 与三油酸甘油酯一起用于相分离研究

用巨型 POPC 脂质体研究了非离子去污剂对脂质体的影响。洗涤剂浓度升高导致管状突起，然后在球形脂质体上形成压痕。洗涤剂浓度较高时，脂质体发生破裂。

Biochem/physiol Actions

2-油酰-1-棕榈锡-sn-甘油-3-磷酸胆碱 (POPC) 可以减小与气液界面相关的表面张力。它可以有效减轻肺泡塌陷和肺水肿。POPC通常可用作一种模型脂质，用于生物物理实验。 它在接触臭氧时进行氧化分解。

General description

2-油酰-1-棕榈锡-sn-甘油-3-磷酸胆碱 (POPC) 与哺乳动物磷脂的组成类似。它包括sn-1 位置的一条饱和链（棕榈酸）和sn-2 位置的一条不饱和链（油酸）。它是良好的EPC合成替代品。POPC与肺泡膜相关，是一种肺表面活性剂。
通过单一水合步骤形成负载有所选分子的无热原的，成分明确的脂质体。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000512209
0000512209
0000508410
0000508410
0000486158

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