P2795
植物鞘氨醇盐酸盐 盐酸盐
别名:
4-羟基鞘氨醇, D-核糖-1,3,4-三羟基-2-十八胺, D-核糖-2-氨基十八-1,3,4-三醇, PHS
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经验公式（希尔记法）:
C18H39NO3 · HCl
化学文摘社编号:
分子量:
353.97
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
InChI
1S/C18H39NO3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20;/h16-18,20-22H,2-15,19H2,1H3;1H/t16-,17+,18-;/m0./s1
SMILES string
Cl.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO
InChI key
GDKAAHDFPOWGQE-RXQQAGQTSA-N
form
powder
greener alternative product score
old score: 19
new score: 9
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greener alternative product characteristics
Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
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sustainability
Greener Alternative Product
greener alternative category
lipid type
sphingolipids
storage temp.
−20°C
Quality Level
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Biochem/physiol Actions
植物鞘氨醇是一种长链类鞘氨醇碱，广泛存在于酵母、植物和动物（包括哺乳动物）中。在酵母中，它可能通过激活 AGC 型蛋白激酶（Pkh1、Pkh2、Ypk1、Ypk2 和 Sch9）参与介导热应激反应。它在人类癌细胞系中具有促凋亡作用。PHS 直接或通过激活 p38MAPK 途径诱导 ΔΨm，并从线粒体释放细胞色素 c。这导致 caspase 9 激活，然后 caspase 3 激活和程序性细胞死亡。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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