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Merck
CN

P2795

Sigma-Aldrich

植物鞘氨醇盐酸盐 盐酸盐

greener alternative

别名:

4-羟基鞘氨醇, D-核糖-1,3,4-三羟基-2-十八胺, D-核糖-2-氨基十八-1,3,4-三醇, PHS

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About This Item

经验公式(希尔记法):
C18H39NO3 · HCl
CAS号:
分子量:
353.97
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.25

形式

powder

质量水平

环保替代产品得分

old score: 19
new score: 9
Find out more about DOZN™ Scoring

环保替代产品特性

Less Hazardous Chemical Syntheses
Safer Solvents and Auxiliaries
Use of Renewable Feedstocks
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

环保替代产品分类

脂质类型

sphingolipids

储存温度

−20°C

SMILES字符串

Cl.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO

InChI

1S/C18H39NO3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20;/h16-18,20-22H,2-15,19H2,1H3;1H/t16-,17+,18-;/m0./s1

InChI key

GDKAAHDFPOWGQE-RXQQAGQTSA-N

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生化/生理作用

植物鞘氨醇是一种长链类鞘氨醇碱,广泛存在于酵母、植物和动物(包括哺乳动物)中。在酵母中,它可能通过激活 AGC 型蛋白激酶(Pkh1、Pkh2、Ypk1、Ypk2 和 Sch9)参与介导热应激反应。它在人类癌细胞系中具有促凋亡作用。PHS 直接或通过激活 p38MAPK 途径诱导 ΔΨm,并从线粒体释放细胞色素 c。这导致 caspase 9 激活,然后 caspase 3 激活和程序性细胞死亡。

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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