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安全信息

P2772

Sigma-Aldrich

L-α-磷脂酰胆碱

egg yolk, Type XI-E, 100 mg/mL in chloroform, ≥99%, solution

别名:

1,2-二酰基-sn-甘油-3-胆碱磷酸, 3-sn-磷脂酰胆碱, L-α-卵磷脂, Azolectin, PC

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About This Item

CAS号:
8002-43-5
Beilstein:
5209585
UNSPSC代码:
51321705
NACRES:
NA.25

生物来源

egg yolk

质量水平

200

类型

Type XI-E

方案

≥99%

表单

solution

浓度

100 mg/mL in chloroform

官能团

phospholipid

脂质类型

phosphoglycerides

储存温度

−20°C

SMILES字符串

[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/C\C=C/CCCCC)COC(=O)CCCCCCCCCCCCCCC)OCC[N+](C)(C)C

InChI

1S/C42H80NO8P/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2/h14,16,20-21,40H,6-13,15,17-19,22-39H2,1-5H3/b16-14-,21-20-/t40-/m1/s1

InChI key

JLPULHDHAOZNQI-ZTIMHPMXSA-N

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相关类别

应用

<ul>
<li><strong>Fabrication of Microalgae Oil Vesicles for Drug Delivery Applications:</strong> This study highlights the use of L-a-Phosphatidylcholine in creating microalgae oil vesicles, showing promise for encapsulating and delivering hydrophobic drugs effectively (Lin YC et al., 2024).</li>
<li><strong>Terpenes-Modified Lipid Nanosystems for Temozolomide, Improving Cytotoxicity against Glioblastoma Human Cancer Cells In Vitro:</strong> L-a-Phosphatidylcholine is employed to formulate terpene-modified lipid nanosystems, enhancing the solubility and bioactivity of temozolomide for glioblastoma treatment (Pashirova TN et al., 2023).</li>
<li><strong>Mitochondria-Targeted Lipid Nanoparticles Loaded with Rotenone as a New Approach for the Treatment of Oncological Diseases:</strong> Utilizing L-a-Phosphatidylcholine, this research developed mitochondria-targeted lipid nanoparticles, potentially offering a novel strategy for cancer therapy (Vasileva L et al., 2023).</li>
</ul>

生化/生理作用

脑磷脂脑中的主要结构磷脂，包含脂肪总量的约15%；主要局限于灰质。

制备说明

P2772 is supplied as a solution in chloroform. The same product is available as a lyophilized powder as Product No. P3556.

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3

靶器官

Central nervous system, Liver,Kidney

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

易制毒化学品（2类）
危险化学品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000364875
0000305023
0000364875
0000305023
0000284869

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Alexander M Dizhoor et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(45), 11662-11672 (2008-11-07)
The G90D rhodopsin mutation is known to produce congenital night blindness in humans. This mutation produces a similar condition in mice, because rods of animals heterozygous (D+) or homozygous (D+/+) for this mutation have decreased dark current and sensitivity, reduced
Yoichi Yamazaki et al.
The Journal of biological chemistry, 289(20), 13792-13800 (2014-04-03)
Rhodopsin undergoes rearrangements of its transmembrane helices after photon absorption to transfer a light signal to the G-protein transducin. To investigate the mechanism by which rhodopsin adopts the transducin-activating conformation, the local environmental changes in the transmembrane region were probed
Alexander Vogel et al.
Biophysical journal, 107(1), 114-125 (2014-07-06)
Estradiol (E2) and E2 oleate associate with high-density lipoproteins (HDLs). Their orientation in HDLs is unknown. We studied the orientation of E2 and E2 oleate in membranes and reconstituted HDLs, finding that E2 and E2 oleate are membrane-associated and highly
Dariusz Latowski et al.
European journal of biochemistry, 269(18), 4656-4665 (2002-09-17)
This paper describes violaxanthin de-epoxidation in model lipid bilayers. Unilamellar egg yolk phosphatidylcholine (PtdCho) vesicles supplemented with monogalactosyldiacylglycerol were found to be a suitable system for studying this reaction. Such a system resembles more the native thylakoid membrane and offers
V Künemund et al.
The Journal of cell biology, 106(1), 213-223 (1988-01-01)
We investigated whether the L2/HNK-1 carbohydrate epitope, expressed by two unusual glycolipids and several neural adhesion molecules, including L1, neural cell adhesion molecule, J1, and the myelin-associated glycoprotein, is involved in adhesion. Monoclonal L2 antibodies, the L2/HNK-1-reactive, sulfate-3-glucuronyl residue carrying
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