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表单
buffered aqueous glycerol solution
质量水平
比活
~850 units/mg protein
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
cow ... PPM2C(280891)
一般描述
Pyruvate dehydrogenase phosphatase (PDP) (EC 3.1.3.43) contains two genetically and biochemically different isoforms, PDP1 and PDP2. PDP1 is widely distributed and is composed of two subunits PDP1c, a catalytic subunit and PDP1r, a flavoprotein with a bound FAD.
生化/生理作用
Insulin-activated Mg2+-dependent and Ca2+-stimulated mitochondrial protein phosphatase specific for the pyruvate dehydrogenase complex.
Pyruvate dehydrogenase phosphatase catalytic subunit 1 (PDP1) catalyzes a Mg2+,-Ca2+ mediated dephosphorylation and activation of E1. PDP1 plays a crucial role in the regulation of pyruvate dehydrogenase complex (PDC) activity.
单位定义
One unit will releases 1 nmol of inorganic phosphate from 32P-labeled pyruvate dehydrogenase complex per min at 30 °C, pH 7.0.
外形
Solution in 50 μl of 50 mM Tris-HCl, pH 7.0, containing 14 mM β-mercaptoethanol, 1 mM benzamidine, 0.1 mM PMSF, 1 mM EDTA, and 50% glycerol.
警示用语：
Warning
危险声明
危险分类
Skin Sens. 1
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Purification of Bovine Kidney and Heart Pyruvate Dehydrogenaseb Phosphatase on Sepharose Derivatized with the Pyruvate Dehydrogenase Complex
Pratt ML, et al.
European Journal of Biochemistry, 125, 349-355 (1982)
Down?regulation of Pyruvate Dehydrogenase Phosphatase in Obese Subjects is a Defect that Signals Insulin Resistance
Piccinini M, et al.
Obesity Research, 13, 678-686 (2005)
Structural Requirements within the Lipoyl Domain for the Ca2+-dependent Binding and Activation of Pyruvate Dehydrogenase Phosphatase Isoform 1 or Its Catalytic Subunit
Turkan A, et al.
The Journal of Biological Chemistry, 277, 14976-14985 (2002)
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