产品名称
单克隆抗 PSD95 小鼠抗, clone 7E3-1B8, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
7E3-1B8, monoclonal
form
buffered aqueous solution
mol wt
antigen 95 kDa
species reactivity
rat
technique(s)
immunofluorescence: 1:500
immunoprecipitation (IP): suitable
western blot: 1:2,000
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
rat ... Dlg4(29495)
Application
Biochem/physiol Actions
与重组和天然大鼠PSD95反应。通过用大鼠海马细胞进行免疫荧光,观察到与NMDA受体在突触位点染色相一致的染色模式,与其在受体簇中的拟议作用一致。 建议用冷甲醇固定。
突触后密度95(PSD-95)在双向突触可塑性中起重要作用,这是学习和记忆所必需的重要过程。在诱导可塑性时,其动力学增加。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
DLG4(圆盘大 MAGUK 支架蛋白 4)基因编码突触后密度 95 (PSD95) 蛋白。突触后密度 95 (PSD-95) 蛋白是一种突触支架蛋白,也是膜相关鸟苷酸激酶 (MAGUK) 家族蛋白。它的 N 末端有 3 个 PDZ 结构域,后跟一个 Src 同源 3 (SH3) 结构域和一个鸟苷酸激酶 (GK) 结构域。该基因位于人类染色体 17p13.1 上。
Immunogen
重组大鼠 PSD95(突触后密度 95 kDa)。
Physical form
含有 0.05% 叠氮化钠的磷酸盐缓冲盐水溶液。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
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Postsynaptic density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity
Wu Q, et al.
The Journal of biological chemistry, jbc-M117 (2017)
Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues
Stathakis D G, et al.
Genomics, 44(1), 71-82 (1997)
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