推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
7E3-1B8, monoclonal
表单
buffered aqueous solution
分子量
antigen 95 kDa
种属反应性
rat
技术
immunofluorescence: 1:500
immunoprecipitation (IP): suitable
western blot: 1:2,000
同位素/亚型
IgG2a
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
rat ... Dlg4(29495)
一般描述
DLG4（圆盘大 MAGUK 支架蛋白 4）基因编码突触后密度 95 (PSD95) 蛋白。突触后密度 95 (PSD-95) 蛋白是一种突触支架蛋白，也是膜相关鸟苷酸激酶 (MAGUK) 家族蛋白。它的 N 末端有 3 个 PDZ 结构域，后跟一个 Src 同源 3 (SH3) 结构域和一个鸟苷酸激酶 (GK) 结构域。该基因位于人类染色体 17p13.1 上。
特异性
与重组和天然大鼠PSD95反应。通过用大鼠海马细胞进行免疫荧光，观察到与NMDA受体在突触位点染色相一致的染色模式，与其在受体簇中的拟议作用一致。 建议用冷甲醇固定。
免疫原
重组大鼠 PSD95（突触后密度 95 kDa）。
应用
生化/生理作用
突触后密度95(PSD-95)在双向突触可塑性中起重要作用，这是学习和记忆所必需的重要过程。在诱导可塑性时，其动力学增加。
外形
含有 0.05% 叠氮化钠的磷酸盐缓冲盐水溶液。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Nora Overlack et al.
Vision research, 48(3), 400-412 (2007-10-10)
The human Usher syndrome (USH) is the most common form of combined deaf-blindness. Usher type I (USH1), the most severe form, is characterized by profound congenital deafness, constant vestibular dysfunction and prepubertal-onset of retinitis pigmentosa. Five corresponding genes of the
Lindsey I Sinclair et al.
Neuropathology and applied neurobiology, 41(4), 533-543 (2015-01-07)
Cerebral ischaemia is the defining pathophysiological abnormality in most forms of vascular dementia (VAD), but the pathogenesis of the dementia remains poorly understood. In Alzheimer's disease (AD), there is early loss of synaptic proteins, but these have been little studied
Linxiao Wang et al.
Journal of neurochemistry, 144(3), 255-270 (2017-12-02)
Epilepsy is a chronic brain disease affecting millions of individuals. Kainate receptors, especially kainate-type of ionotropic glutamate receptor 2 (GluK2), play an important role in epileptogenesis. Recent data showed that GluK2 could undergo post-translational modifications in terms of S-nitrosylation (SNO)
Chongbo Zhong et al.
eNeuro, 4(1) (2017-03-10)
Altered neuregulin 1 (Nrg1)/ErbB signaling and glutamatergic hypofunction have been implicated in the pathophysiology of schizophrenia. Here, we employed gene chimeric ventral hippocampus (vHipp)-nucleus accumbens (nAcc) coculture from mouse, electrophysiology, immunocytochemistry, FM1-43 vesicle fusion, and electron microscopy techniques to examine
Lindsey I Sinclair et al.
Journal of Alzheimer's disease : JAD, 59(3), 1123-1137 (2017-07-22)
Possession of APOEɛ4 is a strong risk factor for late-onset Alzheimer's disease and is associated with loss of synaptic proteins in the elderly even in the absence of Alzheimer's disease. We hypothesized that ɛ4 allele possession in non-demented adults aged
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