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Merck
CN

P246

单克隆抗 PSD95 小鼠抗

clone 7E3-1B8, purified immunoglobulin, buffered aqueous solution

别名:

Anti-MRD62, Anti-PSD95, Anti-SAP-90, Anti-SAP90

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
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产品名称

单克隆抗 PSD95 小鼠抗, clone 7E3-1B8, purified immunoglobulin, buffered aqueous solution

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

7E3-1B8, monoclonal

form

buffered aqueous solution

mol wt

antigen 95 kDa

species reactivity

rat

technique(s)

immunofluorescence: 1:500
immunoprecipitation (IP): suitable
western blot: 1:2,000

isotype

IgG2a

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

Gene Information

rat ... Dlg4(29495)

Application

成功使用该抗体的应用以及相关同行评审论文如下所示。
免疫细胞化学(1 篇)
免疫荧光(1 篇)
免疫印迹(1 篇)

Biochem/physiol Actions

与重组和天然大鼠PSD95反应。通过用大鼠海马细胞进行免疫荧光,观察到与NMDA受体在突触位点染色相一致的染色模式,与其在受体簇中的拟议作用一致。 建议用冷甲醇固定。
突触后密度95(PSD-95)在双向突触可塑性中起重要作用,这是学习和记忆所必需的重要过程。在诱导可塑性时,其动力学增加。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

DLG4(圆盘大 MAGUK 支架蛋白 4)基因编码突触后密度 95 (PSD95) 蛋白。突触后密度 95 (PSD-95) 蛋白是一种突触支架蛋白,也是膜相关鸟苷酸激酶 (MAGUK) 家族蛋白。它的 N 末端有 3 个 PDZ 结构域,后跟一个 Src 同源 3 (SH3) 结构域和一个鸟苷酸激酶 (GK) 结构域。该基因位于人类染色体 17p13.1 上。

Immunogen

重组大鼠 PSD95(突触后密度 95 kDa)。

Physical form

含有 0.05% 叠氮化钠的磷酸盐缓冲盐水溶液。

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存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Lindsey I Sinclair et al.
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Ketamine causes psychotic episodes and is often used as pharmacological model of psychotic-like behavior in animals. There is increasing evidence that molecular mechanism of its action is more complicated than just N-methyl-D-aspartic acid (NMDA) receptor antagonism and involves interaction with
Postsynaptic density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity
Wu Q, et al.
The Journal of biological chemistry, jbc-M117 (2017)
Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues
Stathakis D G, et al.
Genomics, 44(1), 71-82 (1997)

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