P2371
帕米膦酸钠 二钠盐 水合物
≥95% (NMR), Bone resorption inhibitor, solid
别名:
3-氨基-1-羟基-1-膦酰基丙烷膦酸 二钠盐 水合物
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关于此项目
经验公式（希尔记法）:
C3H9NO7P2Na2 · xH2O
化学文摘社编号:
分子量:
279.03 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
260-647-1
MDL number:
产品名称
帕米膦酸钠 二钠盐 水合物, ≥95% (NMR), solid
InChI key
TVQNUQCYOOJTMK-UHFFFAOYSA-L
InChI
1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2
SMILES string
O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O
assay
≥95% (NMR)
form
solid
color
white
mp
300 °C
solubility
H2O: 28 mg/mL
originator
Novartis
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
帕米膦酸二钠具有阻断Wnt和β-catenin信号转导的能力，其可调节骨髓间充质干细胞（BMMSC）的成骨分化。它还可以减少胆红素受损的细胞凋亡，并帮助了来自人乳牙的干细胞发育成牙本质功能障碍。
骨吸收抑制剂；法呢基二磷酸合酶的抑制剂（IC50= 200 nM）。
Features and Benefits
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Despite substantial variability in individual risk of skeletal complications, patients with metastatic bone disease are treated with bisphosphonates at the same dose and dosing interval. This study assessed the feasibility of conducting a randomized trial of less frequent bisphosphonate administration
Coralie Leblicq et al.
Pediatric blood & cancer, 60(5), 741-747 (2012-09-25)
Osteonecrosis (ON) is a severe complication of acute lymphoblastic leukemia (ALL) treatments. Recent studies suggest that bisphosphonates might reduce pain and loss of motor function in patients with ON. We assessed the effects of pamidronate compared to standard care in
Pamidronate decreases bilirubin-impaired cell death and improves dentinogenic dysfunction of stem cells from human deciduous teeth
Yamaza H, et al.
Stem Cell Research & Therapy, 9(1), 303-303 (2018)
Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/beta-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro
Xu Y, et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 75(10), 2135-2143 (2017)
Amber L Watters et al.
Oral surgery, oral medicine, oral pathology and oral radiology, 115(2), 192-200 (2012-10-06)
We report long-term follow-up of patients with intravenous bisphosphonate-related osteonecrosis of the jaw (BRONJ). Medical and dental histories, including type and duration of bisphosphonate treatment and comorbidities, were analyzed and compared with clinical course of 109 patients with BRONJ at
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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