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质量水平
检测方案
≥95% (NMR)
形式
solid
颜色
white
mp
300 °C
溶解性
H2O: 28 mg/mL
创始人
Novartis
储存温度
2-8°C
SMILES字符串
O.[Na+].[Na+].NCCC(O)(P(O)([O-])=O)P(O)([O-])=O
InChI
1S/C3H11NO7P2.2Na.H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;1H2/q;2*+1;/p-2
InChI key
TVQNUQCYOOJTMK-UHFFFAOYSA-L
生化/生理作用
帕米膦酸二钠具有阻断Wnt和β-catenin信号转导的能力,其可调节骨髓间充质干细胞(BMMSC)的成骨分化。它还可以减少胆红素受损的细胞凋亡,并帮助了来自人乳牙的干细胞发育成牙本质功能障碍。
骨吸收抑制剂;法呢基二磷酸合酶的抑制剂(IC50= 200 nM)。
特点和优势
这种化合物是环核苷酸研究的特色产品。点击此处发现更多特色环核苷酸产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。
警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Materials (Basel, Switzerland), 13(9) (2020-05-07)
Medication-related osteonecrosis of the jaw (MRONJ) is a side effect of bisphosphonate therapy, characterised by exposed necrotic bone. The soft tissues of the oral mucosa no longer provide a protective barrier and MRONJ patients experience pain, infections and difficulties eating.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(18), 2347-2357 (2013-05-22)
The aim of the International Myeloma Working Group was to develop practice recommendations for the management of multiple myeloma (MM) -related bone disease. An interdisciplinary panel of clinical experts on MM and myeloma bone disease developed recommendations based on published
Current opinion in supportive and palliative care, 6(3), 342-347 (2012-06-20)
More than 10 years ago evidence emerged that bisphosphonate therapy especially in malignant bone diseases is associated with renal complications. The nature of renal injury from bisphosphonates has become clearer in recent years. Pamidronate can rarely cause (collapsing) focal segmental
PloS one, 7(9), e44868-e44868 (2012-10-03)
It is unclear whether the new anti-catabolic agent denosumab represents a viable alternative to the widely used anti-catabolic agent pamidronate in the treatment of Multiple Myeloma (MM)-induced bone disease. This lack of clarity primarily stems from the lack of sufficient
Asian Pacific journal of cancer prevention : APJCP, 13(9), 4373-4378 (2012-11-22)
Hypercalcemia is mainly caused by bone resorption due to either secretion of cytokines including parathyroid hormone-related protein (PTHrP) or bone metastases. However, hypercalcemia may occur in patients with or without bone metastases. The present study aimed to describe the effect
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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