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Merck
CN
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P2191

Sigma-Aldrich

聚（D,L-丙交酯-co-乙交酯）

lactide:glycolide (50:50), mol wt 30,000-60,000

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别名:
LACTEL® B6010-2, PLGA
线性分子式:
[C3H4O2]x[C2H2O2]y
MDL编号:
MFCD00131930
UNSPSC代码:
12352211
PubChem化学物质编号:
24898286
NACRES:
NA.25

投料比

lactide:glycolide (50:50)

质量水平

100

分子量

30,000-60,000

储存温度

−20°C

SMILES字符串

OCC(O)=O.CC(O)C(O)=O

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一般描述

聚（D，L-丙交酯-共-乙交酯）是一种可生物降解的生物相容性聚合物，可用于药物输送。它可用于治疗类风湿性关节炎、溃疡性结肠炎、克罗恩病、炎性肺病、以及眼部炎性疾病。聚（D，L-丙交酯-共-乙交酯）可作为潜在的癌症治疗靶标起作用。

应用

聚（D，L-丙交酯-共-乙交酯）已经用于在凝胶中提高和维持乳酸盐单体水平，其浓度与皮肤伤口有关。

特点和优势

控释生物活性剂、缝线和可生物吸收植入器件。

外形

具有生物相容性且可生物降解的聚合物。

法律信息

Lactel is a registered trademark of Evonik Corp

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. Product P2191, Poly(D,L-lactide-co-glycolide), is a compound that is useful as a time-release agent in delivery systems such as herbicides, pesticides, and drugs.  What is the rate of degradation?

    The higher the lactic acid to glycolic acid ratio, the slower is the degradation rate of the polymer.  Molecular weight of the polymer is a contributing factor to the degradation; the lower the molecular weight, the faster the degradation rate of the polymer.  

  6. What is the glass transition temperature of Product P2191, Poly(D,L-lactide-co-glycolide)?

    The glass transition is 45-50°C; the melting point is amorphous.

  7. What is the viscosity of Product P2191, Poly(D,L-lactide-co-glycolide)?

    The viscosity of this product is lot-specific and can be found in the Certificate of Analysis.

  8. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Characterization of biodegradable poly (D, L-lactide-co-glycolide) polymers and microspheres
Hausberger AG and DeLuca PP
Journal of Pharmaceutical and Biomedical Analysis, 13(6), 747-760 (1995)
PLGA-based nanoparticles: an overview of biomedical applications
Danhier F, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 161(2), 505-522 (2012)
Habibun Nabi et al.
Parasitology research, 116(1), 359-370 (2016-10-28)
Toxoplasmosis is one of the most common zoonotic protozoal diseases. Recent advances in biotechnology have produced recombinant protein, which are immunogenic, and progress in nano-pharmaceutics has generated encapsulated protein in nanospheres, which are suitable for vaccine delivery. DNA was extracted
Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms
Hunt TK, et al.
Antioxidants & Redox Signaling, 9(8), 1115-1124 (2007)
Ahmed A Abd-Rabou et al.
Biological trace element research, 193(2), 377-389 (2019-05-09)
Colon cancer in men and breast cancer in women are regarded as major health burdens, accounting for majority of cancer diagnoses globally. Doxorubicin (DOX) resistance in breast and colon cancers represents the main reason of unsuccessful therapy. The rationale of
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