推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~62 kDa
种属反应性
mouse, human
技术
indirect immunofluorescence: 5-10 μg/mL using differentiated mouse NIH3T3-L1 cells.
western blot (chemiluminescent): 1-2 μg/mL using whole extract of differentiated mouse NIH3T3-L1 cells
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PLIN(5346)
mouse ... Plin(103968)
rat ... Plin(25629)
一般描述
脂被蛋白是白色和褐色脂肪细胞内用于贮存中性脂质的脂滴的表面蛋白。肾上腺皮质、卵巢中的类固醇生成细胞和睾丸间质细胞存在内含胆固醇酯的较小脂滴，其表面也包被少量的脂被蛋白。脂滴包被蛋白具有多种同工型，这是由于差异剪接事件引起的。脂滴包被蛋白A在脂肪细胞和类固醇生成细胞中含量最高。脂滴包被蛋白B是脂肪细胞中的次要形式。类固醇生成细胞选择性表达脂滴包被蛋白C和D。
免疫原
与人脂滴包被蛋白A的氨基酸残基492-505相对应的合成肽，其中C-末端添加了与KLH偶联的半胱氨酸。相应的序列在小鼠和大鼠中相差一个残基。
生化/生理作用
脂滴包被蛋白可作为分子开关，通过保护甘油三酯防止其水解而抑制基础的脂肪分解，参与调控脂肪细胞的甘油三酯贮存。脂滴包被蛋白还通过激素敏感脂肪酶（HSL）和非HSL来增强环磷酸腺苷（cAMP）依赖蛋白激酶（PKA）激活的脂肪分解。脂被蛋白敲除小鼠的脂肪组织减少，并且能抵制饮食导致的肥胖。它们的脂质贮存脂滴包被未被PKA磷酸化的脂肪分化相关蛋白（ADRP，adipophilin）。
外形
溶于含有15 mM 氮化钠的0.01M磷酸盐缓冲盐水（pH 7.4）。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Franziska B Albrecht et al.
Gels (Basel, Switzerland), 8(10) (2022-10-27)
Adipose tissue is related to the development and manifestation of multiple diseases, demonstrating the importance of suitable in vitro models for research purposes. In this study, adipose tissue lobuli were explanted, cultured, and used as an adipose tissue control to
Hao Yang et al.
Diabetes, 65(11), 3396-3409 (2016-08-25)
Obesity and type 2 diabetes are associated with impaired mitochondrial function in adipose tissue. To study the effects of primary deficiency of mitochondrial energy metabolism in fat, we generated mice with adipose-specific deficiency of fumarate hydratase (FH), an integral Krebs
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation
Sztalryd C, et al.
The Journal of Cell Biology, 161(6), 1093-1103 (2003)
Samantha Murphy et al.
PloS one, 5(12), e15030-e15030 (2011-01-05)
Lipid droplets (LDs) are dynamic cytoplasmic organelles containing neutral lipids and bounded by a phospholipid monolayer. Previous studies have suggested that LDs can undergo constitutive homotypic fusion, a process linked to the inhibitory effects of fatty acids on glucose transporter
Yi-Shiuan Tzeng et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 33(4), 679-690 (2017-11-10)
Bone and bone marrow serve as an imperative ecosystem to various types of cells participating in critical body functions. The chemokine Cxcl12, also known as stromal cell-derived factor 1 (Sdf1), is one of the communication factors in the marrow microenvironment
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