所有图片(1)
别名:
S-(+)-1- [（4-（二甲氨基）-3-甲基苯基）甲基]-5-（二苯乙酰基）-4,5,6,7-四氢-1H-咪唑并 [4,5-c] 吡啶-6-羧酸 二(三氟乙酸) 盐 水合物
经验公式（希尔记法）:
C31H32N4O3 · 2C2HF3O2 · xH2O
CAS号:
分子量:
736.66 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.32
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检测方案
≥98% (HPLC)
形式
powder
储存条件
desiccated
溶解性
H2O: 10 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CN(C)c1ccc(Cn2cnc3CN([C@@H](Cc23)C(O)=O)C(=O)C(c4ccccc4)c5ccccc5)cc1C
InChI
1S/C31H32N4O3.2C2HF3O2.H2O/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24;2*3-2(4,5)1(6)7;/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38);2*(H,6,7);1H2/t28-;;;/m0.../s1
InChI key
PTSUEYBWHKDYBS-FPCIESGBSA-N
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应用
PD123,319 二（三氟醋酸盐）水合物已用于以下实验研究：
- 测定血管紧张素 Ⅱ (AngⅡ) 对肺泡液体清除率 (AFC) 的影响。
- 研究 PD123319 对 AngII 诱导的腹主动脉瘤 (AAA) 的影响。
- 研究其在血管平滑肌细胞 (VSMCs) 培养中对 AngⅡ 诱导的 LRP1 过表达及功能的影响。
生化/生理作用
PD123,319 二（三氟醋酸盐）水合物是一种广泛使用的血管紧张素 II AT2 受体 (AT2R) 拮抗剂，在体外 和体内 研究 AT2 受体的角色 。不与 AT2 受体相互作用，增加 AngII 诱导的腹主动脉瘤 (AAA)。
注意
吸湿
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
PD123319 augments angiotensin II-induced abdominal aortic aneurysms through an AT2 receptor-independent mechanism.
Daugherty A
PLoS ONE, 8(4), e61849-e61849 (2013)
Angiotensin II's role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: amygdalar angiotensin receptors and panic.
Johnson PL
Progress in Neuro-Psychopharmacology, 44, 248-256 (2013)
Kalhara R Menikdiwela et al.
Scientific reports, 9(1), 8481-8481 (2019-06-13)
The Renin Angiotensin System (RAS), a key regulator of blood pressure has been linked to metabolic disorders. We have previously reported that adipose overexpression of angiotensinogen in mice (Agt-Tg) induces obesity, in part mediated by adipose tissue inflammation, through yet unidentified
The Role of Angiotensin II and Cyclic AMP in Alveolar Active Sodium Transport.
Ismael-Badarneh R
PLoS ONE, 10(7), e0134175-e0134175 (2015)
Yan Sun et al.
Cell death & disease, 10(5), 362-362 (2019-05-03)
Angiotensin II (Ang II) is known to promote proliferation of vascular smooth muscle cells (VSMCs) in vascular remodeling, but whether it has an anti-apoptotic effect needs to be explored. Neuregulin-1 (NRG-1) as a member of the epidermal growth factor family
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