所有图片(4)
About This Item
经验公式（希尔记法）:
C13H19N5 · H2O
CAS号:
分子量:
263.34
EC 号:
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.77
形式
powder
质量水平
颜色
white to beige
溶解性
DMSO: 15 mg/mL, clear
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 40 mg/mL
SMILES字符串
O.CC(N\C(Nc1ccncc1)=N\C#N)C(C)(C)C
InChI
1S/C13H19N5.H2O/c1-10(13(2,3)4)17-12(16-9-14)18-11-5-7-15-8-6-11;/h5-8,10H,1-4H3,(H2,15,16,17,18);1H2
InChI key
AFJCNBBHEVLGCZ-UHFFFAOYSA-N
基因信息
human ... ABCC9(10060) , KCNJ11(3767)
mouse ... Kcnj11(16514)
rat ... Kcna1(24520) , Kcnj1(24521) , Kcnj11(83535) , Kcnj5(29713) , Kcnj8(25472)
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应用
使用吡那地尔：
- 通过注入左前降支用于复极化研究
- 在心室肌细胞中诱导ATP敏感性K+ (KATP)电流，用于电生理检查
- 作为KATP开启剂来治疗心肌细胞
生化/生理作用
K+ 通道激活剂；降压药。
吡那地尔是一种KATP通道激动剂。它可通过防止线粒体膜电位的丢失来保护心肌细胞。它可以防止缺氧/复氧损伤中半胱天冬酶3的激活。
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Jing Xu et al.
Journal of cardiovascular pharmacology, 59(6), 514-522 (2012-02-22)
We investigated the beneficial effect of pinacidil pretreatment on vascular reactivity, calcium sensitivity, and animal survival after hemorrhagic shock, its relationship to protein kinase Cα (PKCα), protein kinase Cε (PKCε), and adenosine. Using hemorrhagic shock rats, the protective effects of
Ivana Barbaric et al.
Cryobiology, 63(3), 298-305 (2011-10-27)
Human embryonic stem cells (hESCs) can be maintained as undifferentiated cells in vitro and induced to differentiate into a variety of somatic cell types. Thus, hESCs provide a source of differentiated cell types that could be used to replace diseased
Jeanne G van der Waal et al.
Frontiers in physiology, 12, 737609-737609 (2021-11-09)
Background: The detection and localization of electrophysiological substrates currently involve invasive cardiac mapping. Electrocardiographic imaging (ECGI) using the equivalent dipole layer (EDL) method allows the noninvasive estimation of endocardial and epicardial activation and repolarization times (AT and RT), but the
Electrophysiological analyses of transgenic mice overexpressing KCNJ8 with S422L mutation in cardiomyocytes
Watanabe Y, et al.
Journal of Pharmacological Sciences, 135(1), 37-43 (2017)
Milla Mikkola et al.
Stem cells and development, 22(5), 707-716 (2012-10-31)
Lectins are carbohydrate-binding proteins, which occur ubiquitously in nature and are abundant in all living organisms from bacteria to mammals. They have several biological functions among which cell adhesion is well known and characterized. Based on the characterization of the
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