P1537
聚腺苷酸-多尿苷酸 钠盐
double-stranded homopolymer
别名:
聚[A]• 聚[U]
SMILES string
[P](=O)(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O)[n]4c5ncnc(c5nc4)N)(O)O.[P](=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N2C=CC(=O)NC2=O)(O)O
InChI
1S/C10H14N5O7P.C9H13N2O9P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,10-;4-,6-,7-,8-/m11/s1
InChI key
VGQHQOKIMNKUEF-ZLOOHWKQSA-N
form
powder
storage temp.
−20°C
Quality Level
Application
聚腺苷酸-聚尿苷酸（polyAU）是一种双链同型二聚体，具有潜在的治疗活性，尤其是与放射疗法结合使用时。PolyA/U与其他双链和单链聚合物（如poly-A和poly-U）一起用于比较生理化学研究。
Other Notes
双链均聚物
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Polyadenylic acid-polyuridylic acid (poly A : U) and experimental murine brucellosis. II. Macrophages as target cells of poly A : U in experimental brucellosis.
E D Madraso et al.
Immunology, 35(1), 77-84 (1978-07-01)
A Laplanche et al.
Breast cancer research and treatment, 64(2), 189-191 (2001-02-24)
With a median follow-up of 14 years, the combination of polyadenylic-polyuridylic acid plus locoregional radiotherapy (257 patients) has significantly improved disease-free survival (p = 0.03) and significantly reduced the incidence of metastases (p = 0.04) when compared to CMF alone
Nathan W Luedtke et al.
Biochemistry, 42(39), 11391-11403 (2003-10-01)
Semisynthetic aminoglycoside derivatives may provide a means to selectively target viral RNA sites, including the HIV-1 Rev response element (RRE). The design, synthesis, and evaluation of derivatives based upon neomycin B, kanamycin A, and tobramycin conjugates of 9-aminoacridine are presented.
A A Ghazaryan et al.
Journal of biomolecular structure & dynamics, 24(1), 67-74 (2006-06-20)
We employed UV light absorption and circular dichroism (CD) spectroscopic measurements to study the binding of novel water-soluble porphyrins meso-tetra-(4N-allylpyridyl)porphyrin [TAlPyP4], and its Ag containing derivative to the poly(rA)poly(rU) and poly(rI)poly(rC) RNA duplexes. Our results suggest that TAlPyP4 associate with
Abhi Das et al.
Molecular bioSystems, 8(7), 1958-1969 (2012-05-19)
The plant alkaloid aristololactam-β-d-glucoside and the anticancer chemotherapy drug daunomycin are two sugar bearing DNA binding antibiotics. The binding of these molecules to three double stranded ribonucleic acids, poly(A)·poly(U), poly(I)·poly(C) and poly(C)·poly(G), was studied using various biophysical techniques. Absorbance and
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