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Merck
CN
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文件

P1499

Sigma-Aldrich

紫檀芪

≥97% (HPLC), solid

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别名:
紫檀, 3,5-二甲氧基-4'-羟基茋, 4-[(1E)-2-（3,5-二甲氧基苯基）乙烯基] 苯酚
经验公式（希尔记法）:
C16H16O3
CAS号:
537-42-8
分子量:
256.30
MDL编号:
MFCD00238710
UNSPSC代码:
12352200
PubChem化学物质编号:
24724573
NACRES:
NA.77

质量水平

100

检测方案

≥97% (HPLC)

形式

solid

储存条件

protect from light

溶解性

DMSO: >20 mg/mL
H2O: insoluble

储存温度

2-8°C

SMILES字符串

COc1cc(OC)cc(\C=C\c2ccc(O)cc2)c1

InChI

1S/C16H16O3/c1-18-15-9-13(10-16(11-15)19-2)4-3-12-5-7-14(17)8-6-12/h3-11,17H,1-2H3/b4-3+

InChI key

VLEUZFDZJKSGMX-ONEGZZNKSA-N

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一般描述

紫檀芪(反式-3,5-二甲氧基-4-羟基芪)抗氧化剂是白藜芦醇的类似物，存在于蓝莓、树木和几种葡萄中。

应用

紫檀芪已用于：
  • 研究其抗氧化应激活性以及在核转录因子E2相关因子2(Nrf2)-抗氧化反应元件(ARE)信号转导通路中的调节作用
  • 确定其对激素耐受性乳腺癌细胞雌激素受体α(ERα)转录激活的影响
  • 通过MTT(3-[4,5-二甲基噻唑-2-基]-2,5二苯基四氮唑溴化物)活力检测法研究其对人表皮样癌细胞(A-431)中2-氯乙基乙基硫醚(CEES)的细胞毒性的影响。

生化/生理作用

紫檀芪对几种恶性肿瘤具有抗癌作用，因此可作为活性抗癌药物。在雌激素受体阳性和阴性乳腺癌细胞系中，它可激活细胞凋亡并抑制细胞活性。
抗氧化、抗增殖、细胞凋亡诱导、抗高血糖、抗糖尿病。

注意

空气敏感性

象形图

CorrosionEnvironment
GHS05,GHS09

警示用语：

Danger

危险声明

H318,H411

危险分类

Aquatic Chronic 2 - Eye Dam. 1

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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