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Merck
CN

P1372

帕罗西汀 马来酸盐

≥98% (HPLC), Selective serotonin reuptake inhibitor, solid

别名:

(3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate salt, BRL-29060, FG-7051

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关于此项目

经验公式（希尔记法）:
C19H20FNO3 · C4H4O4
化学文摘社编号:
64006-44-6
分子量:
445.44
UNSPSC Code:
12352200
PubChem Substance ID:
329820091
NACRES:
NA.77
MDL number:
MFCD01742665

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产品名称

帕罗西汀 马来酸盐, ≥98% (HPLC), solid

SMILES string

OC(=O)\C=C/C(O)=O.Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

InChI key

AEIUZSKXSWGSRU-QXGDPHCHSA-N

InChI

1S/C19H20FNO3.C4H4O4/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;5-3(6)1-2-4(7)8/h1-6,9,14,17,21H,7-8,10-12H2;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,17-;/m0./s1

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: ~12 mg/mL
H2O: insoluble

originator

GlaxoSmithKline

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... SLC6A4(6532)

相关类别

Biochem/physiol Actions

Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache.
Paroxetine maleate is a selective serotonin reuptake inhibitor; antidepressant.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold with the permission of Glaxo­Smith­Kline

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000356719
0000356719
0000355449
0000355449
0000226620

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Supportive Oncology E-Book (2011)
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (2015)
Paroxetine: a review
Bourin M, et al.
Cns Drug Reviews, 7(1), 25-47 (2001)
Nicolas Pallet et al.
Proteomics, 13(7), 1108-1120 (2013-02-26)
The stress status of the apoptotic cell can promote phenotypic changes that have important consequences on the immunogenicity of the dying cell. Autophagy is one of the biological processes activated in response to a stressful condition. It is an important
David Germann et al.
Profiles of drug substances, excipients, and related methodology, 38, 367-406 (2013-05-15)
Paroxetine hydrochloride (3S-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine hydrochloride (or (-)-(3S,4R)-(4-(p-fluorophenyl)-3-[[3,4-(methylenedioxy)-phenoxy]methyl]piperidine hydrochloride), a phenylpiperidine derivative, is a selective serotonin reuptake inhibitor. Paroxetine is indicated for the treatment of depression, generalized anxiety disorder, obsessive-compulsive disorder, panic disorder, posttraumatic stress disorder, and social anxiety disorder. The physicochemical
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