推荐产品
生物来源
human
质量水平
方案
≥98% (HPLC)
表单
powder
分子量
362.38
储存条件
(Keep container tightly closed in a dry and well-ventilated place)
技术
activity assay: suitable
杂质
22.6-23.8% Nitrogen
51.9-54.1% carbon
溶解性
water: 25 mg/mL, cloudy, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H]3CCC(=O)N3
InChI
1S/C16H22N6O4/c17-14(24)12-2-1-5-22(12)16(26)11(6-9-7-18-8-19-9)21-15(25)10-3-4-13(23)20-10/h7-8,10-12H,1-6H2,(H2,17,24)(H,18,19)(H,20,23)(H,21,25)/t10-,11-,12-/m0/s1
InChI key
XNSAINXGIQZQOO-SRVKXCTJSA-N
基因信息
human ... TRH(7200) , TRHR(7201)
mouse ... Trhr(22045)
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Amino Acid Sequence
Glp-His-Pro-NH2
一般描述
Research area: Cell Signaling
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.
Thyrotropin releasing hormone (TRH) is a tripeptide hypothalamic regulatory hormone, encoded by the gene mapped to human chromosome 3q13.3-q21. TRH is expressed in a variety of organs including central nervous system (CNS) and gastrointestinal tract, prostate, pancreas, thyroid, heart.
应用
Thyrotropin-releasing hormone has been used as a media supplement to study its effects on stimulating the secretion of prolactin (PRL) from somatolactotroph GH3 cells by enzyme immunometric assay. It has also been used to study its effects on the regulation of energy homeostasis in the central nervous system (CNS) in response to essential amino-acid deprivation.
生化/生理作用
Thyrotropin releasing hormone (TRH) stimulates production and secretion of thyrotropin (TSH) and prolactin from the anterior pituitary.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.
It also plays a vital role as a neurotransmitter and neuromodulator. Thyrotropin-releasing hormone modulates human hair follicle functions and plays a vital role in stimulating hair growth.TRH receptor activated by TRH activates various signal transduction pathways, which mediates the formation of two-second messenger molecules, inositol 1,4,5-trisphosphate, and 1,2-diacylglycerol. TRH expressed in pancreatic β cells aids in the positive regulation of insulin secretion.
促进垂体前叶生成和分泌促甲状腺素 (TSH)。
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
抗体
产品编号
说明
价格
相关产品
产品编号
说明
价格
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
Erzsébet Gáspár et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(2), 393-403 (2009-10-15)
Thyrotropin-releasing hormone (TRH) is the most proximal component of the hypothalamic-pituitary-thyroid axis that regulates thyroid hormone synthesis. Since transcripts for members of this axis were detected in cultured normal human skin cells and since human hair follicles (HFs) respond to
Thyrotropin-Releasing Hormone
Jackson I M D
The New England Journal of Medicine, 306, 145-155 (1982)
Laura Domínguez et al.
Brain, behavior and evolution, 71(3), 231-246 (2008-04-03)
To improve knowledge of the peptidergic systems in the brain of amphibians we have conducted a comparative analysis of the distribution of TRH immunoreactive cell bodies and fibers in three species of urodeles. Fiber labeling was observed in all main
M Heinflink et al.
The Journal of clinical endocrinology and metabolism, 79(2), 650-652 (1994-08-01)
Activation of TRH receptors (TRH-R) stimulates a signal transduction pathway that leads to the formation of two second messenger molecules, inositol 1,4,5-trisphosphate and 1,2-diacylglycerol. It has been suggested that TRH may also cause an elevation of another second messenger, cAMP.
Vladimír Štrbák
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 50(1), 378-384 (2018-10-05)
Thyrotropin releasing hormone (TRH; pGlu-His-ProNH2) is expressed also in pancreatic β cells where it is colocalized in secretory granules with insulin. High perinatal changes of the TRH gene expression and TRH concentrations in rat pancreatic islets coincide with the perinatal
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