P126
Pirenperone
>97%, solid
别名:
3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2-methyl-4H-pyrido-[1,2-a] pyrimidin-4-one, R-47,465
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关于此项目
经验公式（希尔记法）:
C23H24FN3O2
化学文摘社编号:
分子量:
393.45
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
278-213-5
MDL number:
InChI key
HXCNRYXBZNHDNE-UHFFFAOYSA-N
InChI
1S/C23H24FN3O2/c1-16-20(23(29)27-12-3-2-4-21(27)25-16)11-15-26-13-9-18(10-14-26)22(28)17-5-7-19(24)8-6-17/h2-8,12,18H,9-11,13-15H2,1H3
SMILES string
CC1=C(CCN2CCC(CC2)C(=O)c3ccc(F)cc3)C(=O)N4C=CC=CC4=N1
assay
>97%
form
solid
color
light yellow
solubility
0.1 M HCl: 11 mg/mL, methanol: 2.5 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 5.0 mg/mL
Quality Level
Gene Information
human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)
Biochem/physiol Actions
5-HT2 serotonin receptor antagonist.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J P Valentin et al.
Methods and findings in experimental and clinical pharmacology, 17(4), 267-271 (1995-05-01)
We investigated the usefulness of the pithed rat model to determine the relative potencies of 5-HT2A/2C receptor antagonists following acute intravenous and oral administration in inhibiting 5-HT-induced pressor responses. The 5-HT2A/2C receptor antagonists, pirenperone, ketanserin, and ritanserin, all dose-dependently inhibited
D Fiorella et al.
Psychopharmacology, 119(2), 222-230 (1995-05-01)
m-Chlorophenylpiperazine (mCPP), a major metabolite of the atypical antidepressant trazadone, has been observed to produce marked physiological and behavioral effects in both humans and animals. These effects have been attributed to the interaction of mCPP with serotonergic receptors. The present
D Paul et al.
Psychopharmacology, 100(1), 98-101 (1990-01-01)
The selective serotonin type-2 (S2) receptor blocker pirenperone (0.24 mg/kg, SC) attenuates morphine-produced tail-flick antinociception in intact rats, but not in rats with transected spinal cords. These results suggest that S2 receptor blockade does not affect intraspinal opioid antinociception. Together
S Ahlenius et al.
Psychopharmacology, 98(4), 440-444 (1989-01-01)
5-Hydroxy-L-tryptophan (5-HTP), 25 mg kg-1 IP, in combination with the peripheral 5-HTP decarboxylase inhibitor benserazide, 25 mg kg-1 IP, and the selective inhibitor of neuronal 5-hydroxytryptamine (5-HT) re-uptake, zimeldine, 10 mg kg-1 IP, suppressed lordosis in ovariectomized female rats, treated
H H Berendsen et al.
European journal of pharmacology, 135(3), 279-287 (1987-03-31)
The induction of penile erections by a variety of compounds with a direct or indirect effect on serotonin (5HT) receptors was investigated in rats. L-5-Hydroxy-tryptophan (L-5HTP) induced penile erections when co-administered with nialamide and the peripheral decarboxylase inhibitor benserazide, indicating
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