P103
(S)-(-)-3-(3-羟基苯基)-N-丙基哌啶 盐酸盐
≥98% (HPLC), solid
别名:
S-(-)-3-PPP, 丙克拉莫
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关于此项目
经验公式（希尔记法）:
C14H21NO · HCl
化学文摘社编号:
分子量:
255.78
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C14H21NO.ClH/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12;/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3;1H/t13-;/m1./s1
SMILES string
Cl.CCCN1CCC[C@H](C1)c2cccc(O)c2
InChI key
NRHUDETYKUBQJT-BTQNPOSSSA-N
assay
≥98% (HPLC)
form
solid
color
white
solubility
H2O: 150 mg/mL (Solutions should be freshly prepared.), ethanol: slightly soluble (Solutions should be freshly prepared.)
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815)
Biochem/physiol Actions
Dopamine autoreceptor agonist; postsynaptic dopamine receptor antagonist.
Legal Information
Sold with the permission of Astra Pharmaceutical Co.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
J Arnt et al.
Psychopharmacology, 81(3), 199-207 (1983-01-01)
The pharmacological profile of the enantiomers of the proposed selective dopamine (DA) autoreceptor agonist 3-PPP [3-(3-hydroxyphenyl)-N-n-propylpiperidine] has been studied. In vitro both enantiomers showed weak DA agonistic activity, and (--)-3-PPP some DA antagonistic effect on DA-stimulated adenylate cyclase activity. Both
B K Koe et al.
European journal of pharmacology, 161(2-3), 263-266 (1989-02-28)
Binding of i.v. administered (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ([3H]3-PPP) in the brain of intact mice is antagonized dose responsively by sigma receptor ligands. The correlation of potencies for inhibition of binding in vivo and in vitro indicates that sigma receptors in mouse brain
S Hjorth et al.
Psychopharmacology, 81(2), 89-99 (1983-01-01)
The two enantiomers of the putative centrally acting dopamine (DA) autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine, 3-PPP (Hjorth et al. 1981), were pharmacologically evaluated. An extensive series of biochemical and behavioural experiments unexpectedly revealed that both (+)- and (-)-3-PPP showed clear, but differential
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