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方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
H2O: 150 mg/mL (Solutions should be freshly prepared.)
ethanol: slightly soluble (Solutions should be freshly prepared.)
SMILES字符串
Cl.CCCN1CCC[C@H](C1)c2cccc(O)c2
InChI
1S/C14H21NO.ClH/c1-2-8-15-9-4-6-13(11-15)12-5-3-7-14(16)10-12;/h3,5,7,10,13,16H,2,4,6,8-9,11H2,1H3;1H/t13-;/m1./s1
InChI key
NRHUDETYKUBQJT-BTQNPOSSSA-N
基因信息
human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815)
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生化/生理作用
Dopamine autoreceptor agonist; postsynaptic dopamine receptor antagonist.
法律信息
Sold with the permission of Astra Pharmaceutical Co.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
J Arnt et al.
Psychopharmacology, 81(3), 199-207 (1983-01-01)
The pharmacological profile of the enantiomers of the proposed selective dopamine (DA) autoreceptor agonist 3-PPP [3-(3-hydroxyphenyl)-N-n-propylpiperidine] has been studied. In vitro both enantiomers showed weak DA agonistic activity, and (--)-3-PPP some DA antagonistic effect on DA-stimulated adenylate cyclase activity. Both
B K Koe et al.
European journal of pharmacology, 161(2-3), 263-266 (1989-02-28)
Binding of i.v. administered (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ([3H]3-PPP) in the brain of intact mice is antagonized dose responsively by sigma receptor ligands. The correlation of potencies for inhibition of binding in vivo and in vitro indicates that sigma receptors in mouse brain
S Hjorth et al.
Psychopharmacology, 81(2), 89-99 (1983-01-01)
The two enantiomers of the putative centrally acting dopamine (DA) autoreceptor agonist 3-(3-hydroxyphenyl)-N-n-propylpiperidine, 3-PPP (Hjorth et al. 1981), were pharmacologically evaluated. An extensive series of biochemical and behavioural experiments unexpectedly revealed that both (+)- and (-)-3-PPP showed clear, but differential
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