P0928
7-羟基吩噁嗪酮二戊醚
≥98% (TLC), Fluorimetric Cytochrome P450 substrate, powder
别名:
7-(戊氧基)-3H-吩噁嗪-3-酮
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关于此项目
经验公式（希尔记法）:
C17H17NO3
化学文摘社编号:
分子量:
283.32
NACRES:
NA.47
PubChem Substance ID:
UNSPSC Code:
12161501
MDL number:
Beilstein/REAXYS Number:
8394939
产品名称
7-羟基吩噁嗪酮二戊醚,
InChI
1S/C17H17NO3/c1-2-3-4-9-20-13-6-8-15-17(11-13)21-16-10-12(19)5-7-14(16)18-15/h5-8,10-11H,2-4,9H2,1H3
SMILES string
CCCCCOc1ccc2N=C3C=CC(=O)C=C3Oc2c1
InChI key
ZPSOKQFFOYYPKC-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
solubility
acetonitrile: 0.95- 1.05 mg/mL, clear, orange
storage temp.
2-8°C
Quality Level
相关类别
General description
Resorufin pentyl ether is an analog of resazurin. Resorufin is a redox probe which is colorless and non-fluorescent in its reduced state. On oxidation, it fluoresces red. Resorufin is used widely as an indicator in microbiological media. It can be used to differentiate between actively metabolizing cells and inactive or dead cells.
Application
Resorufin pentyl ether has been used as a substrate to study the effects of Kaempferia parviflora extract on mouse hepatic cytochrome P450 enzymes.
Biochem/physiol Actions
Fluorimetric substrate for cytochrome P450 linked enzymes, CYP2B and CYP2B4.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Modulatory effects of Kaempferia parviflora extract on mouse hepatic cytochrome P450 enzymes
Catheleeya Mekjaruskul
Journal of Ethnopharmacology, 141(3) (2012)
A Pietersma et al.
Free radical research, 28(2), 137-150 (1998-06-30)
The present study was undertaken to investigate the hypothesis that multiple oxygen radical generating systems contribute to the tumor necrosis factor (TNF) alpha-stimulated transcriptional activation of the vascular cell adhesion molecule (VCAM)-1 in endothelial cells. Experimental evidence has implicated the
V Burkina et al.
Ecotoxicology and environmental safety, 79, 148-152 (2012-01-17)
Little is known about the effects of the cardiovascular drug verapamil (VRP) on metabolic processes in fish. Most calcium channel blockers including VRP are metabolized by cytochrome P450 (CYP450) enzymes. In this study we investigated the in vivo effect of
Canan Sapmaz et al.
Drug and chemical toxicology, 43(1), 13-21 (2018-05-19)
Morin is a flavonoid which is present in many plants. Endosulfan and 7,12-dimethylbenz[a]anthracene (DMBA) are toxic chemicals that humans are exposed to in their daily lives. In this study, the protective role of morin was investigated in endosulfan and DMBA
Antibacterial activity of resazurin-based compounds against Neisseria gonorrhoeae in vitro and in vivo
Deanna M
International Journal of Antimicrobial Agents (2016)
商品
Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.
一期生物转化反应在药物上引入或暴露官能团，目的是增加化合物的极性。尽管一期药物代谢发生在大多数组织中，但代谢的主要和首过部位发生在肝循环期间。
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