所有图片(4)
About This Item
经验公式（希尔记法）:
C22H31NO2
CAS号:
分子量:
341.49
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
生物来源
synthetic (organic)
质量水平
无菌性
non-sterile
方案
≥97%
表单
powder, crystals or chunks
技术
cell culture | mammalian: suitable
溶解性
chloroform: methanol (1:1): 50 mg/mL, clear, colorless to faintly yellow (with heat)
运输
ambient
储存温度
2-8°C
SMILES字符串
C[C@@]12[C@](C[C@@H](C#N)[C@@H]2C(C)=O)([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC1
InChI
1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1
InChI key
VSBHRRMYCDQLJF-ZDNYCOCVSA-N
应用
5-Pregnen-3β-ol-20-one-16α-carbonitrile has been used:
- in the induction of cytochrome P450
- as pregnane X receptor (PXR) activator in human liver cell lines.
生化/生理作用
Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
>199.9 °F - closed cup
闪点(°C)
> 93.3 °C - closed cup
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
Bin Zhang et al.
Endocrinology, 151(12), 5721-5729 (2010-10-22)
The androgen-androgen receptor signaling pathway plays an important role in the pathogenesis of prostate cancer. Accordingly, androgen deprivation has been the most effective endocrine therapy for hormone-dependent prostate cancer. Here, we report a novel pregnane X receptor (PXR)-mediated and metabolism-based
Nuclear receptor PXR, transcriptional circuits and metabolic relevance
Ihunnah CA, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1812(8), 956-963 (2011)
Katsuhide Igarashi et al.
The Journal of toxicological sciences, 37(2), 373-380 (2012-04-03)
The human steroid and xenobiotic receptor (SXR), (also known as pregnane X receptor PXR, and NR1I2) is a low affinity sensor that responds to a variety of endobiotic, nutritional and xenobiotic ligands. SXR activates transcription of Cytochrome P450, family 3
Aik Jiang Lau et al.
The Journal of pharmacology and experimental therapeutics, 335(3), 771-780 (2010-08-27)
Ginkgo biloba extract activates pregnane X receptor (PXR), but how this occurs is not known. Therefore, we investigated the mechanism of PXR activation by the extract and the role of five individual terpene trilactones in the activation. In a cell-based
Guncha Taneja et al.
Scientific reports, 9(1), 6663-6663 (2019-05-02)
Cytochrome P450 (CYP)3A is the most abundant CYP enzyme in the human liver, and a functional impairment of this enzyme leads to unanticipated adverse reactions and therapeutic failures; these reactions result in the early termination of drug development or the
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