P0472
毛果芸香碱 盐酸盐
meets USP testing specifications
别名:
(3S,4R)-4,5-二氢-3-乙基-4-(1-甲基-1H-咪唑-5-基甲基)-2(3H)-呋喃酮 盐酸盐
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关于此项目
经验公式（希尔记法）:
C11H16N2O2 · HCl
化学文摘社编号:
分子量:
244.72
UNSPSC Code:
12352200
NACRES:
NA.21
PubChem Substance ID:
EC Number:
200-212-5
Beilstein/REAXYS Number:
4034491
MDL number:
InChI key
RNAICSBVACLLGM-GNAZCLTHSA-N
InChI
1S/C11H16N2O2.ClH/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2;/h5,7-8,10H,3-4,6H2,1-2H3;1H/t8-,10-;/m0./s1
SMILES string
Cl.CC[C@H]1[C@H](COC1=O)Cc2cncn2C
agency
USP/NF, meets USP testing specifications
form
solid
mp
202-205 °C (lit.)
application(s)
pharmaceutical (small molecule)
Gene Information
human ... CHRM1(1128), CHRM3(1131)
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Biochem/physiol Actions
非选择性毒蕈碱型乙酰胆碱受体激动剂；用于诱导癫痫实验模型。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
法规信息
涉药品监管产品
此项目有
Maxime Lévesque et al.
Seizure, 25, 18-25 (2015-02-04)
Mesial temporal lobe epilepsy (MTLE) is the most prevalent type of partial epileptic disorders. In this study, we have analyzed the impact of levetiracetam (LEV) in the pilocarpine model of MTLE. Sprague-Dawley rats (n=19) were injected with pilocarpine (380 mg/kg
Manuela Mazzuferi et al.
Annals of neurology, 74(4), 560-568 (2013-05-21)
Epigenetic mechanisms involved in transcriptional regulation of multiple molecular pathways are potentially attractive therapeutic interventions for epilepsy, because single target therapies are unlikely to provide both anticonvulsant and disease-modifying effects. A selection of epilepsy-related gene expression data sets were retrieved
Kathleen Heng et al.
Epilepsia, 54(9), 1535-1541 (2013-07-16)
The role of granule cell axon (mossy fiber) sprouting in temporal lobe epileptogenesis is unclear and controversial. Rapamycin suppresses mossy fiber sprouting, but its reported effects on seizure frequency are mixed. The present study used high-dose rapamycin to more completely
Kevin D Phelan et al.
Molecular pharmacology, 83(2), 429-438 (2012-11-29)
Seizures are the manifestation of highly synchronized burst firing of a large population of cortical neurons. Epileptiform bursts with an underlying plateau potential in neurons are a cellular correlate of seizures. Emerging evidence suggests that the plateau potential is mediated
Jiandong Yu et al.
Journal of neurophysiology, 109(7), 1746-1763 (2013-01-18)
Temporal lobe epilepsy is associated with loss of interneurons and inhibitory dysfunction in the dentate gyrus. While status epilepticus (SE) leads to changes in granule cell inhibition, whether dentate basket cells critical for regulating granule cell feedforward and feedback inhibition
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