P0314
Prostaglandin F2α methyl ester
~5 mg/mL in methyl acetate, ≥95% (HPLC)
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关于此项目
经验公式（希尔记法）:
C21H36O5
化学文摘社编号:
分子量:
368.51
UNSPSC Code:
12352200
PubChem Substance ID:
EC Number:
201-185-2
MDL number:
InChI key
KRDFNHLEMLCWKD-GWSKAPOCSA-N
InChI
1S/C22H38O5/c1-3-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27-4-2/h6,9,14-15,17-21,23-25H,3-5,7-8,10-13,16H2,1-2H3/b9-6-,15-14+/t17-,18+,19+,20-,21+/m0/s1
SMILES string
CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OCC
assay
≥95% (HPLC)
concentration
~5 mg/mL in methyl acetate
storage temp.
−20°C
Biochem/physiol Actions
Constricts an isolated human smooth muscle; methyl ester form of prostaglandin F2α which is a luteolytic prostaglandin (induces parturition; pulmonary vasoconstrictor).
Packaging
Packaged under Argon.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Central nervous system
supp_hazards
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
15.0 °F
flash_point_c
-9.45 °C
ppe
Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
B Wu et al.
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 13(2), 177-180 (1997-05-01)
The effect of 15-Mt-PGF2 alpha on CCl4-induced injury of primary cultured hepatocytes was studied. 15-Mt-PGF2 alpha treatment (2 mg/L) significantly decreased CCl4 (10 mmol/L)-induced damages of primary cultured rat heptocytes as indicated by decreases GPT and GOT leakage and LPO
A Alm et al.
Progress in clinical and biological research, 312, 447-458 (1989-01-01)
A lipid-soluble PG ester such as PGF2 alpha-IE reduces IOP in the human eye when given in considerably lower doses than are needed for the tromethamine salt of this PG to do so. However, with the pharmaceutical composition now used
B V Praveen et al.
International journal of clinical pharmacology, therapy, and toxicology, 30(1), 7-12 (1992-01-01)
A prospective randomized, controlled study was done to compare the efficacy and safety of 15(s) 15 Me PGF2 alpha intravesical instillation and 1% alum vesical irrigation in the control of vesical hematuria which persisted even after continuous bladder irrigation with
The ocular hypotensive effects and side effects of prostaglandins on the eyes of experimental animals.
L Z Bito et al.
Progress in clinical and biological research, 312, 349-368 (1989-01-01)
Zhonghua fu chan ke za zhi, 25(1), 31-34 (1990-01-01)
Abortion was attempted in 316 healthy women in early pregnancy within 7 weeks with the RU486 alone (600mg in a single oral dose) or in combination with a PG (15-dl-methyl-PGF2 alpha-methyl-ester) 1 mg suppository. The result of using RU 486
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