P0113
PQ401
≥98% (HPLC), powder
别名:
IGF-1R Inhibitor II, N-(5-Chloro-2-methoxyphenyl)-N′-(2-methylquinolin-4-yl)urea
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关于此项目
经验公式（希尔记法）:
C18H16ClN3O2
化学文摘社编号:
分子量:
341.79
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
PQ401, ≥98% (HPLC), powder
InChI
1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)
SMILES string
COc1ccc(Cl)cc1NC(=O)Nc2cc(C)nc3ccccc23
InChI key
YBLWOZUPHDKFOT-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: >10 mg/mL
H2O: <2 mg/mL
storage temp.
2-8°C
Quality Level
相关类别
Application
PQ401 has been used as:
- an insulin growth factor-1 receptor (IGF-IR) inhibitor in H1299 cells to test its effect on migration suppression
- a reference inhibitor in dose-response measurements studies
- an IGF1R inhibitor in sirtuin 6 (SIRT6)-deficient cardiomyocytes to test its effect on hypertrophy inhibition
Biochem/physiol Actions
PQ401 is an insulin growth factor-1 receptor (IGF-1R) inhibitor.
PQ401, a diaryl urea compound that serves as an anti-glioma agent.
Features and Benefits
This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the InsR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Xiang Zhou et al.
Journal of chemotherapy (Florence, Italy), 28(1), 44-49 (2015-05-15)
Growth factor signalling pathways transduce extra-cellular physiological cues to guide cells to maintain critical cellular functions, including cell proliferation, survival and metabolism. Dysregulation of certain growth factor signalling pathways has been shown as a major route to promote tumourigenesis. Glioma
Jung-Min Choi et al.
Lung cancer (Amsterdam, Netherlands), 90(2), 175-181 (2015-09-08)
Lung cancer is the commonly diagnosed cancer and is the leading cause of cancer-related mortality worldwide. The most prevalent form of lung cancer is NSCLC, comprising 80% of all lung cancer cases, and epidermal growth factor receptor (EGFR) is frequently
Monica Brenca et al.
The Journal of pathology, 238(4), 543-549 (2015-11-27)
Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. The vast majority of GISTs are driven by oncogenic activation of KIT, PDGFRA or, less commonly, BRAF. Loss of succinate dehydrogenase complex activity has been identified
Maria Giovanna Scioli et al.
Journal of tissue engineering and regenerative medicine, 11(8), 2398-2410 (2016-04-15)
Osteochondral lesions due to injury or other pathology commonly result in the development of osteoarthritis and progressive joint destruction. Bioengineered scaffolds are widely studied for regenerative surgery strategies in osteochondral defect management, also combining the use of stem cells, growth
Identification of Novel IGF1R Kinase Inhibitors by Molecular Modeling and High-Throughput Screening.
R Moriev et al.
Acta naturae, 5(2), 90-99 (2013-07-03)
The aim of this study was to identify small molecule compounds that inhibit the kinase activity of the IGF1 receptor and represent novel chemical scaffolds, which can be potentially exploited to develop drug candidates that are superior to the existing
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