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P0099

Sigma-Aldrich

帕潘立酮

≥98% (HPLC)

别名:

3-[2-[4-（6-氟-1,2-苯并异恶唑-3-基）-1-哌啶基] 乙基]-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并 [1,2-a] 嘧啶-4-酮, 9-羟基利培酮

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About This Item

经验公式（希尔记法）:
C23H27FN4O3
CAS号:
144598-75-4
分子量:
426.48
MDL编号:
MFCD00871802
UNSPSC代码:
12352200
PubChem化学物质编号:
329820012
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to brown

溶解性

DMSO: 2 mg/mL, clear (warmed)

创始人

Johnson & Johnson

储存温度

room temp

SMILES字符串

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1

InChI

1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

InChI key

PMXMIIMHBWHSKN-UHFFFAOYSA-N

基因信息

human ... DRD2(1813) , HTR2A(3356)

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相关类别

应用

帕潘立酮已被用作非典型抗精神病药（AAPD），用于研究其预防脂多糖（LPS）激发的产前免疫小鼠精神疾病的功效。它还被用作非典型抗精神病药（AAPD），用于诠释以细菌内毒素脂多糖（LPS）处理的雌性产前小鼠中下丘脑-垂体-肾上腺（HPA）轴的调节。

生化/生理作用

帕利哌酮属于非典型抗精神病药；利培酮的活性代谢产物。

特点和优势

《受体分类和信号转导》手册的多巴胺受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由 强生开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301

危险分类

Acute Tox. 3 Oral

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000386255
0000326158
0000326157
0000326158
0000326157

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Mehrul Hasnain et al.
CNS drugs, 28(10), 887-920 (2014-08-30)
We comprehensively reviewed published literature to determine whether it supported the link between corrected QT (QTc) interval prolongation and torsade de pointes (TdP) for the 11 second-generation antipsychotics and seven second-generation antidepressants commonly implicated in these complications. Using PubMed and
Eliyahu Dremencov et al.
Psychopharmacology, 194(1), 63-72 (2007-05-29)
Paliperidone (9-OH-risperidone) is the main metabolite of the atypical antipsychotic risperidone. While both drugs are potent dopamine (D)2 antagonists, they have quantitative differential affinities for serotonin (5-HT) and norepinephrine (NE) receptor binding sites. The present study aimed to determine if
Umesh Kumar et al.
European journal of pharmacology, 747, 181-189 (2014-09-23)
Studies on animal models provide enough evidences that old age appearance of psychosis on exposures to various insults during critical period of brain development could be prevented by antipsychotic drug treatment. Presently, gestational intervention of the atypical antipsychotic paliperidone (PAL)
Luca Pani et al.
Expert opinion on drug delivery, 6(3), 319-331 (2009-03-26)
The development of paliperidone extended release (ER) may represent a new strategy to improve the pharmacological treatment of schizophrenia. The drug maintains the atypical antipsychotic profile of its parent compound risperidone, but it is associated with an innovative delivery system
Sacheen Kumar et al.
Colloids and surfaces. B, Biointerfaces, 102, 562-568 (2012-10-30)
Solid lipid nanoparticles were prepared and studied for the possibility of entrapment of Paliperidone (PPN) an antipsychotic drug that can be used for the treatment of schizophrenia. Here we report the preparation of Paliperidone loaded solid lipid particles (SLNs) with
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