推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~22 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
immunohistochemistry: 2.5-5 μg/mL using biotin/ExtrAvidin™-Peroxidase staining of formalin-fixed, paraffin-embedded human spinal cord sections
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... PMP22(5376)
mouse ... Pmp22(18858)
rat ... Pmp22(24660)
一般描述
PMP22 (peripheral myelin protein-22) is a tetraspan integral membrane protein, that contains four putative transmembrane domains. It is expressed in the peripheral nervous system. PMP22 is produced by myelinating Schwann cells. It is an important constituent of peripheral myelin. This gene is mapped to human chromosome 17p11.2.
特异性
Anti-PMP22 recognizes human PMP22.
免疫原
synthetic peptide corresponding to amino acid residues 118-133 of human PMP22, with an added cysteine, conjugated to KLH. The corresponding sequence differs by 3 amino acids in rat and mouse.
生化/生理作用
PMP22 (peripheral myelin protein-22) participates in the progression of CNS (central nervous system) myelin. It modulates self-renewal and chemoresistance of gastric cancer cells. Mutation in PMP22 results in Charcot-Marie tooth disease.
PMP22 plays a role in peripheral nerve myelin formation, cell-cell interactions, and cell proliferation. Overexpression of PMP22 is implicated in the neoplastic transformation of normal tissue to pre-malignant lesions and cancer of the pancreas and osteoblasts.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
储存及稳定性
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze at -20 °C in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
法律信息
BiotinTag is a trademark of Sigma-Aldrich Co. LLC
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Shazia Irshad et al.
Science translational medicine, 5(202), 202ra122-202ra122 (2013-09-13)
Many newly diagnosed prostate cancers present as low Gleason score tumors that require no treatment intervention. Distinguishing the many indolent tumors from the minority of lethal ones remains a major clinical challenge. We now show that low Gleason score prostate
Maaike van Dartel et al.
Cancer genetics and cytogenetics, 152(2), 113-118 (2004-07-21)
The peripheral myelin protein (PMP22) gene is highly expressed in peripheral Schwann cells and encodes an important constituent of the myelin sheath. It is also expressed at lower levels in other normal tissues in which the protein is supposed to
A novel missense mutation in peripheral myelin protein-22 causes Charcot-Marie-Tooth disease
Li, Li-Xi and Dong
Chinese Medical Journal (English Edition), 130(15), 1779-1779 (2017)
PMP22 regulates self-renewal and chemoresistance of gastric cancer cells
Cai W, et al.
Molecular Cancer Therapeutics, molcanther-molcan0750 (2017)
G Jackson Snipes et al.
Annals of the New York Academy of Sciences, 883(1), 143-151 (1999-10-01)
The gain of function phenotypes exhibited by the heterozygous Tr, Tr-J, and CMT1A mutations indicate that these mutations interfere with more than the function of a single PMP22 allele. The identification of proteins that interact with PMP22 and that are
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