所有图片(1)
About This Item
经验公式（希尔记法）:
C22H30O6
CAS号:
分子量:
390.47
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white
溶解性
DMSO: 10 mg/mL, clear
储存温度
−20°C
SMILES字符串
C[C@@H]1C[C@]2(OC(C)=O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C
InChI
1S/C22H30O6/c1-11-6-16-20(26,18(11)25)9-14(10-23)7-15-17-19(4,5)21(17,28-13(3)24)8-12(2)22(15,16)27/h6-7,12,15-17,23,26-27H,8-10H2,1-5H3/t12-,15+,16-,17-,20-,21+,22-/m1/s1
InChI key
BOJKFRKNLSCGHY-HXGSDTCMSA-N
应用
Prostratin已被用于逆转人类免疫缺陷病毒-1（HIV-1）的潜伏，并对潜伏HIV-1感染的Jurkat（J-Lat）细胞中长末端重复序列（LTR）的转录激活进行定量。
生化/生理作用
Prostratin是一种不常见的非致癌性佛波酯，它是蛋白激酶C（PKC）的激活剂，也是IKK（IKB激酶）激活介导的核因子KB (NF-KB) 的激活剂。
Prostratin是一种不常见的非致癌性佛波酯，它是蛋白激酶C（PKC）的激活剂，也是IKK（IKB激酶）激活介导的核因子KB（NF-KB）的激活剂。 Prostratin通过诱导潜伏感染细胞系和原代细胞的HIV表达而发挥有效的体外活性，从而对抗HIV潜伏。已有研究提出了其作用机制是激活PKC和NF-kB。Prostratin还通过下调CD4和CXCR4受体而抑制HIV进入靶细胞。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Roberto A Barrero et al.
BMC genomics, 12, 600-600 (2011-12-14)
Euphorbia fischeriana is an important medicinal plant found in Northeast China. The plant roots contain many medicinal compounds including 12-deoxyphorbol-13-acetate, commonly known as prostratin that is a phorbol ester from the tigliane diterpene series. Prostratin is a protein kinase C
L Yu et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(3-4), 239-244 (2011-10-11)
Chinese jujube (also known as Chinese date) is the fruit of Ziziphus jujuba Mill. (Rhamnaceae). As a famous folk medicine, it is used as antidote in traditional Chinese formula, Shi Zao Decoction, to relieve the drastic inflammatory irritant nature of
Brian A DeChristopher et al.
Nature chemistry, 4(9), 705-710 (2012-08-24)
Bryostatin is a unique lead in the development of potentially transformative therapies for cancer, Alzheimer's disease and the eradication of HIV/AIDS. However, the clinical use of bryostatin has been hampered by its limited supply, difficulties in accessing clinically relevant derivatives
Samuel A Williams et al.
The Journal of biological chemistry, 279(40), 42008-42017 (2004-07-31)
A subset of quiescent memory CD4 T cells harboring integrated but transcriptionally silent proviruses poses a currently insurmountable barrier to the eradication of the human immunodeficiency virus (HIV) in infected patients. Induction of HIV gene expression in these latently infected
Flow cytometric analysis of drug-induced HIV-1 transcriptional activity in A2 and A72 J-Lat cell lines
Daniela B and Melanie O
Bio-protocol, 7(10) (2017)
商品
Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.
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