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Merck
CN

P0053

PGLa

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关于此项目

经验公式（希尔记法）:
C88H162N26O22S
化学文摘社编号:
102068-15-5
分子量:
1968.45
UNSPSC Code:
51102829
NACRES:
NA.85

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InChI

1S/C88H162N26O22S/c1-19-48(9)69(113-78(126)52(13)97-66(117)42-95-72(120)50(11)98-79(127)59(31-23-27-36-91)108-85(133)64(44-115)111-77(125)54(15)100-81(129)61(33-38-137-18)104-65(116)41-93)87(135)101-51(12)73(121)96-43-67(118)105-57(29-21-25-34-89)82(130)114-70(49(10)20-2)88(136)103-55(16)74(122)106-60(32-24-28-37-92)83(131)112-68(47(7)8)86(134)102-56(17)76(124)110-63(40-46(5)6)84(132)107-58(30-22-26-35-90)80(128)99-53(14)75(123)109-62(71(94)119)39-45(3)4/h45-64,68-70,115H,19-44,89-93H2,1-18H3,(H2,94,119)(H,95,120)(H,96,121)(H,97,117)(H,98,127)(H,99,128)(H,100,129)(H,101,135)(H,102,134)(H,103,136)(H,104,116)(H,105,118)(H,106,122)(H,107,132)(H,108,133)(H,109,123)(H,110,124)(H,111,125)(H,112,131)(H,113,126)(H,114,130)/t48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,68-,69-,70-/m0/s1

InChI key

PJRSUKFWFKUDTH-JWDJOUOUSA-N

form

solid

solubility

H2O: 1 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, fungi, viruses

mode of action

cell membrane | interferes

storage temp.

2-8°C

Quality Level

200

General description

化学结构：肽

Application

PGLa是一种阳离子抗菌肽(AMP)，最初从青蛙中分离得到。它已经被证明有抗菌，1 抗真菌，2和抗病毒，3 活性。 它被用来研究新的肽片段，来自PGLa和非洲爪蟾多核胃粘膜细胞。

Biochem/physiol Actions

PGLa的前体是蛙皮素和爪蟾肽。 PGLa对革兰氏阴性细菌的作用机制是破坏细胞脂质双层膜。4 它可用于诱导脂双层和细菌细胞膜中的跨膜孔形成。 它与蛙皮素2结合使用可产生协同效应。

Other Notes

500ug
保存于密闭容器内，置于干燥通风处。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBQ7151V
SLBN9420V
SLBN5121V
SLBD6810V
SLBC8846V

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Feng Hou et al.
International journal of antimicrobial agents, 38(6), 510-515 (2011-10-22)
A new antimicrobial peptide (AMP) named PGLa-H has been isolated from the skin of the African clawed frog (Xenopus laevis) using gel filtration and reverse-phase high-performance liquid chromatography (RP-HPLC). Its amino acid sequence was determined as KIAKVALKAL by Edman degradation
Evgeniy S Salnikov et al.
Biophysical journal, 100(6), 1473-1480 (2011-03-16)
To gain further insight into the antimicrobial activities of cationic linear peptides, we investigated the topology of each of two peptides, PGLa and magainin 2, in oriented phospholipid bilayers in the presence and absence of the other peptide and as
Meng Ao et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 93(2), 551-556 (2010-03-13)
To prepare the Gd-DTPA-loaded poly (lactic-co-glycolic acid) (PLGA) microbubbles for both ultrasound imaging and MRI imaging. Biodegradable high-molecular-weight poly (lactic-co-glycolic acid) (PLGA) was used as an encapsulating vehicle to fabricate a contrast agent composed of gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA)
K S Moore et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 40(3), 367-378 (1992-03-01)
We have characterized a novel peptide-containing cell within the gastric mucosa of Xenopus laevis. The cell is a spherical, multinucleated syncytial structure containing a cytoplasmic space filled with dense rice-shaped granules, and is strikingly similar in morphology to the well-studied
O O Ojo et al.
Biochemical and biophysical research communications, 431(1), 14-18 (2013-01-08)
Skin secretions of several frog species contain host-defense peptides with multiple biological activities including in vitro and in vivo insulin-releasing actions. This study investigates the effects of tigerinin-1R from Hoplobatrachus rugulosus (Dicroglossidae) and magainin-AM1, magainin-AM2, caerulein precursor fragment (CPF-AM1) and
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