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Merck
CN

P0053

PGLa

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关于此项目

经验公式（希尔记法）:
C88H162N26O22S
化学文摘社编号:
102068-15-5
分子量:
1968.45
UNSPSC Code:
51102829
NACRES:
NA.85

主要文件

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InChI

1S/C88H162N26O22S/c1-19-48(9)69(113-78(126)52(13)97-66(117)42-95-72(120)50(11)98-79(127)59(31-23-27-36-91)108-85(133)64(44-115)111-77(125)54(15)100-81(129)61(33-38-137-18)104-65(116)41-93)87(135)101-51(12)73(121)96-43-67(118)105-57(29-21-25-34-89)82(130)114-70(49(10)20-2)88(136)103-55(16)74(122)106-60(32-24-28-37-92)83(131)112-68(47(7)8)86(134)102-56(17)76(124)110-63(40-46(5)6)84(132)107-58(30-22-26-35-90)80(128)99-53(14)75(123)109-62(71(94)119)39-45(3)4/h45-64,68-70,115H,19-44,89-93H2,1-18H3,(H2,94,119)(H,95,120)(H,96,121)(H,97,117)(H,98,127)(H,99,128)(H,100,129)(H,101,135)(H,102,134)(H,103,136)(H,104,116)(H,105,118)(H,106,122)(H,107,132)(H,108,133)(H,109,123)(H,110,124)(H,111,125)(H,112,131)(H,113,126)(H,114,130)/t48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,68-,69-,70-/m0/s1

InChI key

PJRSUKFWFKUDTH-JWDJOUOUSA-N

form

solid

solubility

H2O: 1 mg/mL

antibiotic activity spectrum

Gram-negative bacteria, fungi, viruses

mode of action

cell membrane | interferes

storage temp.

2-8°C

Quality Level

200

General description

化学结构：肽

Application

PGLa是一种阳离子抗菌肽(AMP)，最初从青蛙中分离得到。它已经被证明有抗菌，1 抗真菌，2和抗病毒，3 活性。 它被用来研究新的肽片段，来自PGLa和非洲爪蟾多核胃粘膜细胞。

Biochem/physiol Actions

PGLa的前体是蛙皮素和爪蟾肽。 PGLa对革兰氏阴性细菌的作用机制是破坏细胞脂质双层膜。4 它可用于诱导脂双层和细菌细胞膜中的跨膜孔形成。 它与蛙皮素2结合使用可产生协同效应。

Other Notes

500ug
保存于密闭容器内，置于干燥通风处。

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBQ7151V
SLBN9420V
SLBN5121V
SLBD6810V
SLBC8846V

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