所有图片(1)
About This Item
经验公式（希尔记法）:
C19H16N2O3
CAS号:
分子量:
320.34
MDL编号:
UNSPSC代码:
12352203
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white to off-white
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
Cc1ccc(\C=N\NC(=O)c2ccccc2Oc3ccccc3)o1
InChI
1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+
InChI key
JJEDWBQZCRESJL-DEDYPNTBSA-N
应用
PNU-74654已被：
- 作为β-连环蛋白信号转导抑制剂，研究对乌贼胚漏斗软骨分化的影响
- 作为Wnt信号抑制剂，研究其对前列腺癌细胞系糖原合成酶激酶3 (GSK-3)的抑制作用
- 作为Wnt信号通路抑制剂，研究其对瘦素诱导的乳腺癌细胞增殖的影响
生化/生理作用
PNU-74654 通过阻断 β-连环蛋白和 TCF（T 细胞因子）抑制 Wnt-β。PNU-74654 也是一种抗肿瘤药物。
PNU-74654 通过阻断 β-连环蛋白和 TCF（T 细胞因子）抑制 Wnt-β。PNU-74654 也是一种抗肿瘤药物。Wnt /β-catenin通路（经典通路）的异常激活通过β-catenin和T细胞因子（TCF）之间的相互作用参与驱动不同肿瘤（如结肠癌）的发生/发展，T细胞因子分解细胞增殖和分化中靶基因的表达。在癌细胞系中抑制该通路活性可有效阻断其生长。PNU-74654通过抑制β-catenin和TCF之间的相互作用抑制该通路。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Letícia F Leal et al.
Oncotarget, 6(40), 43016-43032 (2015-10-31)
To date, there is no effective therapy for patients with advanced/metastatic adrenocortical cancer (ACC). The activation of the Wnt/beta-catenin signaling is frequent in ACC and this pathway is a promising therapeutic target. To investigate the effects of the inhibition of
Oscar A Tarazona et al.
Nature, 533(7601), 86-89 (2016-04-26)
The evolution of novel cell types led to the emergence of new tissues and organs during the diversification of animals. The origin of the chondrocyte, the cell type that synthesizes cartilage matrix, was central to the evolution of the vertebrate
Jieun Lee et al.
Biochemical and biophysical research communications, 525(3), 563-569 (2020-03-03)
Supercentenarians (≥110-year-old, SC) are a uniquely informative population not only because they surpass centenarians in age, but because they appear to age more slowly with fewer incidences of chronic age-related disease than centenarians. We reprogramed donor B-lymphoblastoid cell lines (LCL)
R-Q Xin et al.
European review for medical and pharmacological sciences, 24(19), 9932-9939 (2020-10-23)
MicroRNA-329-3p (miR-329-3p) has been shown to be involved in tumor development. But its role in hepatocellular carcinoma has not been explored. Our study aims to explore the effect and mechanism of miR-329-3p on hepatocellular carcinoma development. Hepatocellular carcinoma tissues and
Hong Quan Duong et al.
Cancer research, 78(16), 4533-4548 (2018-06-20)
MAPK signaling pathways are constitutively active in colon cancer and also promote acquired resistance to MEK1 inhibition. Here, we demonstrate that BRAFV600E -mutated colorectal cancers acquire resistance to MEK1 inhibition by inducing expression of the scaffold protein CEMIP through a
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