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质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to off-white
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
CC(C)(C)n1nc(-c2ccc(Cl)cc2)c3c(N)ncnc13
InChI
1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
InChI key
PBBRWFOVCUAONR-UHFFFAOYSA-N
应用
PP2 已被用于:
- 分析 Src/粘着斑激酶（FAK）信号传导对 IQ 结构域 GTP酶激活蛋白 1 （IQGAP1）介导的失巢凋亡抗性的影响
- 用于 Src 抑制以研究其对非小细胞肺癌 （NSCLC） 细胞中表皮生长因子受体（EGFR） 和核因子E 2 相关因子 2（Nrf2） 磷酸化的影响
- 用于MDA-MB-231 乳腺癌细胞中 SRC的药物抑制
生化/生理作用
PP2 是非受体酪氨酸激酶（nRTK） 的Src-家族酪氨酸激酶的选择性抑制剂。它对ζ链TCR相关蛋白激酶70（ZAP-70）和 Janus激酶 2（JAK2）的选择性>10000 倍。PP2 在体外和体内有效地减少宫颈癌增殖。
特点和优势
该化合物是激酶磷酸酶生物学研究的特色产品。 点击此处 ，发现更多特色激酶磷酸酶生物学产品。在 sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
警示用语：
Danger
危险声明
预防措施声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
闪点(°F)
Not applicable
闪点(°C)
Not applicable
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Miharu Shida et al.
Biochimica et biophysica acta. General subjects, 1863(9), 1319-1331 (2019-06-11)
Chondroitin sulfate (CS) chains are prominent extra/pericellular matrix components in the central nervous system (CNS) and can exert positive or negative regulatory effects on neurite outgrowth, depending on the CS structure and the amount. Despite the remarkable abilities of highly
Mika Soma et al.
Frontiers in neuroscience, 12, 282-282 (2018-05-17)
Dendritic spine is a small membranous protrusion from a neuron's dendrite that typically receives input from an axon terminal at the synapse. Memories are stored in synapses which consist of spines and presynapses. Rapid modulations of dendritic spines induced by
Fabio Cattaneo et al.
Phytochemical analysis : PCA, 30(5), 524-534 (2019-06-07)
Sempervivum tectorum L. (Crassulaceae), is a succulent perennial plant widespread in Mediterranean countries and commonly used in traditional medicine for ear inflammation, ulcers and skin rashes as a refrigerant and astringent. To demonstrate the therapeutic effects of the plant, various
Chunxing Zheng et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(52), E7239-E7248 (2015-12-17)
Obesity-associated inflammation is accompanied by the accumulation of adipose tissue macrophages (ATMs), which is believed to predispose obese individuals to insulin resistance. CD11b (integrin αM) is highly expressed on monocytes and macrophages and is critical for their migration and function.
Elpetra P M Timmermans-Sprang et al.
Veterinary and comparative oncology, 17(3), 413-426 (2019-05-10)
Human epidermal growth factor 2 (HER2) overexpression leads to aggressive mammary tumour growth. Although the prognosis of HER2+ tumours in humans is greatly improved using biologicals, therapy resistance, which may be caused by increased phosphatidyl-3-kinase (PI3K), rous sarcoma proto-oncogene (cSRC)
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Discover Bioactive Small Molecules for Kinase Phosphatase Biology
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