所有图片(1)
About This Item
经验公式（希尔记法）:
C16H19N5
CAS号:
分子量:
281.36
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to off-white
溶解性
DMSO: >20 mg/mL
储存温度
room temp
SMILES字符串
Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
InChI
1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChI key
ZVPDNRVYHLRXLX-UHFFFAOYSA-N
应用
PP1已用作：
- 肉瘤(Src)家族激酶(SFK)的抑制剂，如造血细胞激酶(hck)和fyn
- 在海马神经元培养中选择Src酪氨酸激酶抑制剂以测试其对神经突生长的影响
- Src激酶阻滞剂，以测试对溴莫尼定(BMD)诱导的细胞外信号激活激酶(ERK1/2)磷酸化的影响
生化/生理作用
PP1 是一种有效的选择性 Src 家族蛋白酪氨酸激酶抑制剂。
PP1是一种吡唑嘧啶化合物，作为三磷酸腺苷(ATP)结合的竞争性抑制剂。它还能抑制蛋白酪氨酸激酶(PTK6)，可用于PTK6阳性乳腺癌恶性肿瘤的治疗管理。
特点和优势
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于其他研究领域中关于生物活性小分子的消息。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Qian Wang et al.
Environmental science and pollution research international, 26(21), 21774-21783 (2019-05-28)
Due to variable amino acid residues at positions 2 and 4, microcystins (MCs) had diversified variants with different toxicities. To evaluate the discrepant toxicity, the inhibition effects of five typical MC variants (with the changed amino acid residues at position
Shunyu Gao et al.
General and comparative endocrinology, 240, 46-60 (2016-10-23)
Neuropeptide Y (NPY) receptors and its ligands, NPY, peptide YY (PYY) and pancreatic polypeptide (PP), are suggested to regulate many physiological processes including food intake in birds. However, our knowledge regarding this avian NPY system remains rather limited. Here, we
Chiyuki Ueshima et al.
Cancer medicine, 6(4), 845-856 (2017-03-24)
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed in a number of tumor cell types. The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing isoforms of this molecule which possess a long cytoplasmic tail (CEACAM1-L) generally play inhibitory roles in cell function
Katyayni Vinnakota et al.
Journal of cellular physiology, 232(12), 3468-3480 (2017-01-18)
The inflammatory milieu plays an important role in colon cancer development and progression. Previously, we have shown that tumor-associated macrophages (TAMs), an important component of the tumor microenvironment, are enriched in tumors compared with normal tissue and confer a poorer
Jun Mori et al.
Blood, 131(10), 1122-1144 (2018-01-06)
Src family kinases (SFKs) coordinate the initiating and propagating activation signals in platelets, but it remains unclear how they are regulated. Here, we show that ablation of C-terminal Src kinase (Csk) and receptor-like protein tyrosine-phosphatase CD148 in mice results in
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