推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to off-white
溶解性
DMSO: >20 mg/mL
储存温度
room temp
SMILES字符串
Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
InChI
1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
InChI key
ZVPDNRVYHLRXLX-UHFFFAOYSA-N
应用
PP1已用作：
- 肉瘤(Src)家族激酶(SFK)的抑制剂，如造血细胞激酶(hck)和fyn
- 在海马神经元培养中选择Src酪氨酸激酶抑制剂以测试其对神经突生长的影响
- Src激酶阻滞剂，以测试对溴莫尼定(BMD)诱导的细胞外信号激活激酶(ERK1/2)磷酸化的影响
生化/生理作用
PP1是一种吡唑嘧啶化合物，作为三磷酸腺苷(ATP)结合的竞争性抑制剂。它还能抑制蛋白酪氨酸激酶(PTK6)，可用于PTK6阳性乳腺癌恶性肿瘤的治疗管理。
PP1 是一种有效的选择性 Src 家族蛋白酪氨酸激酶抑制剂。
特点和优势
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于其他研究领域中关于生物活性小分子的消息。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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Neuropeptide Y (NPY) receptors and its ligands, NPY, peptide YY (PYY) and pancreatic polypeptide (PP), are suggested to regulate many physiological processes including food intake in birds. However, our knowledge regarding this avian NPY system remains rather limited. Here, we
Paolo Mita et al.
The Journal of biological chemistry, 291(49), 25516-25528 (2016-10-27)
URI (unconventional prefoldin RPB5 interactor protein) is an unconventional prefoldin, RNA polymerase II interactor that functions as a transcriptional repressor and is part of a larger nuclear protein complex. The components of this complex and the mechanism of transcriptional repression
Luciana Gneo et al.
Oncotarget, 7(49), 80820-80841 (2016-11-09)
TrkAIII expression in neuroblastoma (NB) associates with advanced stage disease, worse prognosis, post therapeutic relapse, and in NB models TrkAIII exhibits oncogenic activity and promotes chemotherapeutic-resistance. Here, we report a potential therapeutic "Achilles heel" for the TrkAIII oncoprotein in a
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Journal of the American Society of Nephrology : JASN, 30(7), 1220-1237 (2019-06-27)
CD2-associated protein (CD2AP), a slit diaphragm-associated scaffolding protein involved in survival and regulation of the cytoskeleton in podocytes, is considered a "stabilizer" of the slit diaphragm complex that connects the slit diaphragm protein nephrin to the cytoskeleton of the cell.
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