推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CCOC(=O)c1cnn(-c2ccc(NC(=O)\C(Cl)=C(\Cl)Cl)cc2)c1C(F)(F)F
InChI
1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
InChI key
RZHGONNSASQOAY-UHFFFAOYSA-N
生化/生理作用
Pyr3 是一种吡唑类化合物，可强效选择性拮抗 TRPC3。Pyr3 通过与受体胞外侧结合，抑制 TRPC3，从而抑制 B 细胞活化和心肌肥厚。
经典瞬时受体电位 (TRPC) 通道家族的成员是传导 Ca + 2 的离子通道，被膜受体介导的磷脂酶 C (PLC) 活性刺激激活。然而，TRPC3 和其他家族成员也被膜非依赖性甘油二酯 (DAG) 激活。BTP1 和 BTP2 是阻断 TRPC 通道的吡唑类药物，但它们对 TRPC 亚型无特异性。该通道参与多种过程，包括 B 细胞受体 (BCR) 介导的 Ca + 2 振荡、活化 T 细胞核因子 (NFAT) 的活化以及促进心肌肥厚。
经典瞬时受体电位 (TRPC) 通道家族的成员是传导 Ca + 2 的离子通道，被膜受体介导的磷脂酶 C (PLC) 活性刺激激活。然而，TRPC3 和其他家族成员也被膜非依赖性甘油二酯 (DAG) 激活。BTP1 和 BTP2 是阻断 TRPC 通道的吡唑类药物，但它们对 TRPC 亚型无特异性。该通道参与多种过程，包括 B 细胞受体 (BCR) 介导的 Ca + 2 振荡、活化 T 细胞核因子 (NFAT) 的活化以及促进心肌肥厚。
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Maria Cristina D Picardo et al.
PLoS biology, 17(2), e2006094-e2006094 (2019-02-23)
Inspiratory breathing movements depend on pre-Bötzinger complex (preBötC) interneurons that express calcium (Ca2+)-activated nonselective cationic current (ICAN) to generate robust neural bursts. Hypothesized to be rhythmogenic, reducing ICAN is predicted to slow down or stop breathing; its contributions to motor
Naoya Hirata et al.
International journal of molecular sciences, 23(4) (2022-02-27)
Triple-negative breast cancer (TNBC) is a highly aggressive cancer for which targeted therapeutic agents are limited. Growing evidence suggests that TNBC originates from breast cancer stem cells (BCSCs), and elucidation of the molecular mechanisms controlling BCSC proliferation will be crucial
Yi-Fan Wu et al.
Cell & bioscience, 7, 28-28 (2017-05-27)
Chloroquine, a bitter tastant, inhibits Ca In this study, thapsigargin (TG), but not caffeine, induced sustained intracellular Ca These results indicate that chloroquine inhibits Ca
Wenya Du et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 30(4), 1754-1774 (2022-01-26)
Acute pancreatitis (AP) is a common digestive disease without specific treatment, and its pathogenesis features multiple deleterious amplification loops dependent on translation, triggered by cytosolic Ca2+ ([Ca2+]i) overload; however, the underlying mechanisms in Ca2+ overload of AP remains incompletely understood.
Cheng Cai et al.
Archives of toxicology, 93(4), 1009-1020 (2019-02-27)
Particulate matter (PM) is one of the most important environmental issues worldwide, which is associated with not only pulmonary but also cardiovascular diseases. However, the underlying biological mechanisms of PM related cardiovascular dysfunction remained poorly defined, especially mediated by the
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门