推荐产品
形式
powder
颜色
white
溶解性
methanol: 5 mg/mL, clear, colorless
储存温度
2-8°C
SMILES字符串
C[C@@]12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)[C@@]1([H])C[C@@H](O)[C@@]4([H])[C@]2(CC[C@]4([H])[C@@](CCC=C(C)C)(C)O)C
InChI
1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24-,25-,27-,28+,29+,30-/m0/s1
InChI key
PYXFVCFISTUSOO-HKUCOEKDSA-N
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一般描述
人参皂苷代谢物已通过糖皮质激素受体 (GR) 和雌激素受体(ER) 与内皮细胞功能相关。
应用
可将一种达玛烷型四环萜烯皂苷元——丹普烷型二醇[20（R-protopanaxadiol）用于研究其通过糖皮质激素 (GR) 和雌激素 (ER) 受体与内皮细胞功能的结合和调节。原托那沙二醇可用于研究细胞色素P450的分解代谢。与20 (S)-原花粉二醇相比，20 (R)-原花粉二醇可用于比较研究。
WGK
WGK 3
法规信息
新产品
Xin Jin et al.
Fitoterapia, 84, 64-71 (2012-09-26)
As with many other anti-cancer agents, 20(S)-protopanaxadiol (PPD) has a low oral absorption. In this study, in order to improve the oral bioavailability of PPD, the cubic nanoparticles that it contains were used to enhance absorption. Therefore, the cubic nanoparticle
Alain Gulenga Musende et al.
Anti-cancer drugs, 23(5), 543-552 (2012-04-07)
This study focuses on determining the pharmacokinetics, biodistribution, and efficacy of the ginsenoside aglycone protopanaxadiol (aPPD) administered as a single agent in a novel oral dosage formulation. To obtain these data and to characterize the stability of aPPD, appropriate analytical
Eun-Ah Bae et al.
Biological & pharmaceutical bulletin, 25(1), 58-63 (2002-02-05)
When ginsenoside Rg3 was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside Rg3 to ginsenoside Rh2 and protopanaxadiol. The main metabolite was ginsenoside Rh2. 20(S)-ginsenoside Rg3 was quickly transformed to 20(S)-ginsenoside Rh2 or 20(S)-protopanaxadiol in an amount 19-fold
Identification of 20(S)-protopanaxadiol metabolites in human liver microsomes and human hepatocytes.
Liang Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(3), 472-483 (2010-12-09)
20(S)-Protopanaxadiol (PPD, 1) is one of the aglycones of the ginsenosides and has a wide range of pharmacological activities. At present, PPD has progressed to early clinical trials as an antidepressant. In this study, its fate in mixed human liver
Gang Zhen et al.
Science China. Life sciences, 58(11), 1099-1110 (2015-11-14)
Panax ginseng C. A. Meyer is an important traditional herb in eastern Asia. It contains ginsenosides, which are primary bioactive compounds with medicinal properties. Although ginseng has been cultivated since at least the Ming dynasty to increase production, cultivated ginseng
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