InChI
1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24-,25-,27-,28+,29+,30-/m0/s1
SMILES string
C[C@@]12CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)[C@@]1([H])C[C@@H](O)[C@@]4([H])[C@]2(CC[C@]4([H])[C@@](CCC=C(C)C)(C)O)C
InChI key
PYXFVCFISTUSOO-HKUCOEKDSA-N
form
powder
color
white
solubility
methanol: 5 mg/mL, clear, colorless
storage temp.
2-8°C
General description
人参皂苷代谢物已通过糖皮质激素受体 (GR) 和雌激素受体(ER) 与内皮细胞功能相关。
Application
可将一种达玛烷型四环萜烯皂苷元——丹普烷型二醇[20（R-protopanaxadiol）用于研究其通过糖皮质激素 (GR) 和雌激素 (ER) 受体与内皮细胞功能的结合和调节。原托那沙二醇可用于研究细胞色素P450的分解代谢。与20 (S)-原花粉二醇相比，20 (R)-原花粉二醇可用于比较研究。
存储类别
13 - Non Combustible Solids
wgk
WGK 3
法规信息
新产品
此项目有
Eun-Ah Bae et al.
Biological & pharmaceutical bulletin, 25(1), 58-63 (2002-02-05)
When ginsenoside Rg3 was anaerobically incubated with human fecal microflora, all specimens metabolized ginsenoside Rg3 to ginsenoside Rh2 and protopanaxadiol. The main metabolite was ginsenoside Rh2. 20(S)-ginsenoside Rg3 was quickly transformed to 20(S)-ginsenoside Rh2 or 20(S)-protopanaxadiol in an amount 19-fold
Gang Zhen et al.
Science China. Life sciences, 58(11), 1099-1110 (2015-11-14)
Panax ginseng C. A. Meyer is an important traditional herb in eastern Asia. It contains ginsenosides, which are primary bioactive compounds with medicinal properties. Although ginseng has been cultivated since at least the Ming dynasty to increase production, cultivated ginseng
Mi-Hyun Yoo et al.
Applied microbiology and biotechnology, 89(4), 1019-1028 (2010-11-06)
The production of compound K and aglycon protopanaxadiol (APPD) from ginsenoside Rd and ginseng root extract was performed using a recombinant β-glycosidase from Pyrococcus furiosus. The activity for Rd was optimal at pH 5.5 and 95°C with a half-life of
Chenhao Pan et al.
Frontiers in pharmacology, 9, 1538-1538 (2019-02-05)
Osteolysis is a principal reason for arthroplasty failure like aseptic loosening induced by Titanium (Ti) particle. It is a challenge for orthopedic surgeons. Recent researches show that 20(S)-protopanaxadiol can inhibit inflammatory cytokine release in vitro. This study aims to assess
Alain Gulenga Musende et al.
Anti-cancer drugs, 23(5), 543-552 (2012-04-07)
This study focuses on determining the pharmacokinetics, biodistribution, and efficacy of the ginsenoside aglycone protopanaxadiol (aPPD) administered as a single agent in a novel oral dosage formulation. To obtain these data and to characterize the stability of aPPD, appropriate analytical
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持